{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:01:08Z","timestamp":1777917668964,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2000,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and background<\/jats:title>\n                    <jats:p>The question of whether TPN is able to reverse lean body mass depletion in cachectic cancer patients and, in particular, its effect on protein kinetics is a matter of some controversy. This study investigates the impact of TPN on protein kinetics in patients with gastric cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study involved three patients with 14\u201330% weight loss. They were administered a TPN regimen including 33\u201340 kcal\/kg\/day and 1.4\u20131.7 g amino acid\/kg\/day. The protein metabolism was studied before and during TPN using a stable amino acid isotope.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Whole body protein turnover and breakdown did not change during TPN, whereas whole body protein synthesis increased from 3.39 \u00b1 1.04 to 6.05 \u00b1 0.48 g\/kg\/day (P = 0.03). However, the net balance, which was slightly negative prior to TPN, became positive during nutritional support. In the skeletal muscle compartment the synthesis improved with TPN (from 9.38 \u00b1 2.6 nmol\/100 mL\/min to 35.95 \u00b1 3.4 nmol\/100 mL\/min; P = 0.0143), whereas breakdown did not change significantly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TPN triggers a positive metabolic response in cachectic cancer patients. Whether this results in a clinical benefit for the patient requires further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089160008600508","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T12:14:17Z","timestamp":1523880857000},"page":"408-411","source":"Crossref","is-referenced-by-count":15,"title":["Effect of Total Parenteral Nutrition on the Protein Kinetics of Patients with Cancer Cachexia"],"prefix":"10.1177","volume":"86","author":[{"given":"Federico","family":"Bozzetti","sequence":"first","affiliation":[{"name":"Nutritional Support Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Gavazzi","sequence":"additional","affiliation":[{"name":"Nutritional Support Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Centro Euratom, Ispra;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Dworzak","sequence":"additional","affiliation":[{"name":"*Istituto Neurologico Besta, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,9,1]]},"reference":[{"key":"bibr1-030089160008600508","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(81)90074-3"},{"key":"bibr2-030089160008600508","doi-asserted-by":"publisher","DOI":"10.1177\/0148607183007006525"},{"key":"bibr3-030089160008600508","first-page":"127","volume":"11","author":"Burt M.E.","year":"1984","journal-title":"Semin. 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