{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:02:10Z","timestamp":1777917730200,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2001,11]]},"abstract":"<jats:p>\n                    The purpose of this phase II study was to evaluate the clinical efficacy of mitomycin C and vinblastine in patients with anthracycline-resistant metastatic breast cancer. This single-center, non-randomized trial enrolled 39 patients. Eligible patients must have received at least three chemotherapy regimens with epirubicin or CAF and had treatment failure while on chemotherapy or within 6 months of completing therapy. Treatment consisted of mitomycin C at a starting dose of 8 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    on day 1 and vinblastine (8 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    , days 1 and 28). The regimen was repeated every 6 weeks with a 20% dose escalation of both drugs after the first cycle in the absence of grade III hematologic or other toxicity. On an intent-to-treat basis, 38 patients were eligible for assessment; 9 (23.7%, 95% confidence interval 1.92-2.45%) achieved a partial response and 13 (34.2%) had stable disease. The median time to disease progression was 6.21 \u00b14.26 months (range, 1-15; 95% confidence interval, 4.81-7.61), and the median survival was 10.76\u00b17.6 (range, 1-29; 95% confidence interval 8.0-13.1%). Responsive patients had a significantly better survival than those with stable and progressive disease. Treatment was well tolerated. Anemia and neutropenia (grade I-III) developed in 28.9% and 26.3% of the patients, respectively. One patient with grade III granulocytopenia developed fever and infection that required hospitalization. Moderate neurotoxicity, myalgia, constipation, diarrhea and alopecia were observed. No toxic death occurred. Mitomycin C plus vinblastine is an effective and well-tolerated regimen for anthracycline resistant cancer.\n                  <\/jats:p>","DOI":"10.1177\/030089160108700608","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T12:37:26Z","timestamp":1523882246000},"page":"394-397","source":"Crossref","is-referenced-by-count":3,"title":["Mitomycin C and Vinblastine in Anthracycline-resistant Metastatic Breast Cancer: A Phase Ii Study"],"prefix":"10.1177","volume":"87","author":[{"given":"Haralabos P","family":"Kalofonos","sequence":"first","affiliation":[{"name":"Department of Medicine\/Oncology, University Hospital of Patras, Rion 26500, Patras"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adinchi","family":"Onyenadum","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Oncology, University Hospital of Patras, Rion 26500, Patras"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Kosmas","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Oncology, University Hospital of Patras, Rion 26500, Patras"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelos","family":"Koutras","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Oncology, University Hospital of Patras, Rion 26500, Patras"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodoras","family":"Petsas","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital of Patras, Rion 26500, Patras"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasilis","family":"Efthimiou","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Oncology, University Hospital of Patras, Rion 26500, Patras"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitris","family":"Koukouras","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital of Patras, Rion 26500, Patras"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelos","family":"Tzoracolefterakis","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital of Patras, Rion 26500, Patras"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panayiotis","family":"Andrikopoulos","sequence":"additional","affiliation":[{"name":"Department of Surgery, General Hospital of Egio, Achaia, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joannis","family":"Androulakis","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospital of Patras, Rion 26500, Patras"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2001,11,1]]},"reference":[{"key":"bibr1-030089160108700608","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.10.2094"},{"key":"bibr2-030089160108700608","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.12.2886"},{"key":"bibr3-030089160108700608","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9776(96)90031-4"},{"key":"bibr4-030089160108700608","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(95)00398-3"},{"key":"bibr5-030089160108700608","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008208002779"},{"key":"bibr6-030089160108700608","first-page":"1602","volume-title":"Cancer: Principles and Practice of Oncology","author":"Harris J.","year":"1997"},{"key":"bibr7-030089160108700608","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9776(96)90028-4"},{"key":"bibr8-030089160108700608","first-page":"669","volume":"16","author":"Huig 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