{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:02:48Z","timestamp":1777917768939,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:p>The \u201cMisura\u201d project is a retrospective survey, with the aim to evaluate how 5FU is used in the treatment of colorectal cancer in clinical practice in Italian oncology departments. Twenty-four centers participated. Patients seen in the second half of 1998 with colorectal cancer and treated with 5FU were analyzed. Observed patients were 664, 45.9% of patients presented metastatic disease. Biochemical modulation with folinic acid and bolus 5FU was the most used schedule (59%). The De Gramont (LV 5FU2) regimen, alone or with other cytotoxic drugs, was the second most chosen schedule (14%). The most frequent side effect observed was gastrointestinal toxicity. No hematological toxicity was demonstrated in 68.8% of patients. Cutaneous toxicity occurred in 21.1% of patients. 5FU is widely used independently by the stage of disease. In palliative treatment a variety of schedules were administered by the Italian centers, lacking a standard therapy. There are very few surveys investigating oncology clinical practice. A larger survey on this issue is auspicable.<\/jats:p>","DOI":"10.1177\/030089160208800205","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T12:18:38Z","timestamp":1523881118000},"page":"104-109","source":"Crossref","is-referenced-by-count":1,"title":["\u201cMisura\u201d Project: A Retrospective Survey on the Use of 5fluorouracil in the Treatment of Colorectal Cancer in 24 Italian Clinical Centers"],"prefix":"10.1177","volume":"88","author":[{"given":"Paola","family":"Poletti","sequence":"first","affiliation":[{"name":"Unit\u00e0 Operativa di Oncologia Medica, Ospedali Riuniti, Bergamo;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graziella","family":"Pinotti","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Oncologia Medica, Ospedale di Circolo, Varese;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo","family":"Rosati","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Oncologia Medica, Ospedale S Carlo, Potenza;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Luppi","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Oncologia Medica, Policlinico di Modena;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toni","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Oncologia Medica, Ospedale L Pierantoni, Forl\u00ec;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Marinozzi","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Oncologia Medica, Policlinico Umberto I, Rome;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Pucci","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Oncologia Medica, Azienda Ospedaliera, Parma;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Pancera","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Oncologia Medica, Clinica IGEA, Milan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Biasco","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Oncologia Medica, Ospedale Sorsola, Bologna;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Barni","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Oncologia Medica, Ospedale S Gerardo, Monza;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Garufi","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Oncologia Medica, Ospedale Regina Elena, Rome;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Martignoni","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Oncologia Medica, Ospedale S Carlo, Milan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Vison\u00e0","sequence":"additional","affiliation":[{"name":"Glaxo-Wellcome, Verona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Labianca","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Oncologia Medica, Ospedali Riuniti, Bergamo;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,3,1]]},"reference":[{"key":"bibr1-030089160208800205","first-page":"49","volume-title":"Cancer chemotherapy and biotherapy.","author":"Grem J.L.","year":"1996"},{"key":"bibr2-030089160208800205","first-page":"1144","volume-title":"Cancer, principles and practice of oncology","author":"Cohen A.M.","year":"1997","edition":"5"},{"key":"bibr3-030089160208800205","first-page":"4667","volume":"44","author":"Maajewicz P.","year":"1984","journal-title":"Cancer Res"},{"key":"bibr4-030089160208800205","first-page":"1803","volume":"66","author":"Machover D.","year":"1982","journal-title":"Cancer Treat Rep"},{"key":"bibr5-030089160208800205","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.11.1967"},{"key":"bibr6-030089160208800205","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a058047"},{"key":"bibr7-030089160208800205","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199404213301608"},{"key":"bibr8-030089160208800205","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.10.1559"},{"key":"bibr9-030089160208800205","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.5.960"},{"key":"bibr10-030089160208800205","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-122-5-199503010-00001"},{"key":"bibr11-030089160208800205","first-page":"1391","volume":"69","author":"Dewrinko B.","year":"1985","journal-title":"Cancer Treat. 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