{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:03:02Z","timestamp":1777917782785,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and Background<\/jats:title>\n                    <jats:p>In the last ten years validation of the sentinel lymph node (SLN) concept has led to modification of the surgical approach for patients with intermediate-risk cutaneous melanoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Study Design<\/jats:title>\n                    <jats:p>Forty-eight patients affected by cutaneous melanoma with a Breslow thickness between 0.65 and 4 mm were enrolled in the study. Approximately 2 mCi of radiotracer and 1 mL of vital blue dye were injected in each patient around the site of the primary lesion. Lymphoscintigraphy was performed until the lymphatic basin and the respective SLN were localized. The whole surgical procedure consisted of enlargement of the surgical margins followed by localization and excision of the SLN(s) by using both radiotracer and vital dye. Whenever the SLN proved to be histologically positive for metastasis, complete regional lymphadenectomy was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Within 15 minutes of radiotracer administration the lymphatic basin was localized in all 48 patients by lymphoscintigraphy. Vital dye and radiotracer successfully allowed SLN localization and excision in 46 of 48 patients (97%); in one case the SLN was detected by radiotracer alone. The SLN proved to be metastatic in six (13%) of 46 evaluable patients; interestingly, in three of them the presence of metastatic cells was revealed only by immunohistochemistry. All patients with tumor-positive SLNs had primary lesions with a Breslow thickness = 2 mm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sentinel lymphadenectomy is able to identify lymph node involvement in patients with cutaneous melanoma with a Breslow thickness &gt;1 mm, thus avoiding the risks associated with radical regional lymphadenectomy. Lymphoscintigraphy proved to be an important tool to obtain correct preoperative localization of the drainage basin, especially for melanomas located on the face and trunk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089160208800343","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T11:37:19Z","timestamp":1524483439000},"page":"S49-S51","source":"Crossref","is-referenced-by-count":4,"title":["Sentinel Lymphadenectomy in Cutaneous Melanoma"],"prefix":"10.1177","volume":"88","author":[{"given":"O","family":"Buonomo","sequence":"first","affiliation":[{"name":"Clinical Surgery \u2013 Department of Surgery, University of Rome \u201cTor Vergata\u201d c\/o S Eugenio Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Felici","sequence":"additional","affiliation":[{"name":"Clinical Surgery \u2013 Department of Surgery, University of Rome \u201cTor Vergata\u201d c\/o S Eugenio Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AV","family":"Granai","sequence":"additional","affiliation":[{"name":"Clinical Surgery \u2013 Department of Surgery, University of Rome \u201cTor Vergata\u201d c\/o S Eugenio Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Piccirillo","sequence":"additional","affiliation":[{"name":"Clinical Surgery \u2013 Department of Surgery, University of Rome \u201cTor Vergata\u201d c\/o S Eugenio Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"De Liguori Carino","sequence":"additional","affiliation":[{"name":"Clinical Surgery \u2013 Department of Surgery, University of Rome \u201cTor Vergata\u201d c\/o S Eugenio Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Guadagni","sequence":"additional","affiliation":[{"name":"Regina Elena Cancer Institute, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Mariotti","sequence":"additional","affiliation":[{"name":"Medical Oncology \u2013 Department of Surgery, University of Rome \u201cTor Vergata\u201d c\/o S Eugenio Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Orlandi","sequence":"additional","affiliation":[{"name":"Clinical Pathology, University of Rome \u201cTor Vergata\u201d c\/o S Eugenio Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Tipaldi","sequence":"additional","affiliation":[{"name":"Surgical Oncology, S Eugenio Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Cipriani","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, S Eugenio Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Chimenti","sequence":"additional","affiliation":[{"name":"Dermatology \u2013 University of Rome \u201cTor Vergata\u201d c\/o S Eugenio Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Cervelli","sequence":"additional","affiliation":[{"name":"Clinical Surgery \u2013 Department of Surgery, University of Rome \u201cTor Vergata\u201d c\/o S Eugenio Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CU","family":"Casciani","sequence":"additional","affiliation":[{"name":"Clinical Surgery \u2013 Department of Surgery, University of Rome \u201cTor Vergata\u201d c\/o S Eugenio Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Roselli","sequence":"additional","affiliation":[{"name":"Medical Oncology \u2013 Department of Surgery, University of Rome \u201cTor Vergata\u201d c\/o S Eugenio Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,5,1]]},"reference":[{"key":"bibr1-030089160208800343","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1992.01420040034005"},{"key":"bibr2-030089160208800343","doi-asserted-by":"publisher","DOI":"10.1016\/0960-7404(93)90001-F"},{"key":"bibr3-030089160208800343","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199412000-00009"},{"key":"bibr4-030089160208800343","first-page":"71","volume":"11","author":"Pouch\u00e8 A.","year":"2001","journal-title":"Atti 103\u00b0 SIC Bologna"},{"key":"bibr5-030089160208800343","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197702)39:2<456::AID-CNCR2820390214>3.0.CO;2-I"},{"key":"bibr6-030089160208800343","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)08260-3"},{"key":"bibr7-030089160208800343","first-page":"1435","volume":"34","author":"Uren R.F.","year":"1993","journal-title":"J 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