{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:03:31Z","timestamp":1777917811139,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and background<\/jats:title>\n                    <jats:p>Sixty-three patients with local-regionally advanced breast cancer were treated with neoadjuvant chemotherapy consisting of docetaxel (Taxotere), epirubicin, and 5-fluorouracil (TEF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and study design<\/jats:title>\n                    <jats:p>\n                      Preoperatively, patients received four cycles of Taxotere (80 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), epirubicin (60 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), and 5-fluorouracil (500 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), repeated every 21 days. Following completion of four cycles of chemotherapy, appropriate surgery was performed. After the surgery, patients received one cycle of the TEF chemotherapy regimen; following chemotherapy, radiotherapy was applied, and at the end two more cycles of TEF chemotherapy regimen were given.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty-three patients with locally advanced breast cancer were treated. Three patients were excluded from the study before the evaluation of response. Median age of the patients was 50 years (range, 25\u201377). Twenty-seven and 33 patients were premenopausal and postmenopausal, respectively. Thirty-nine patients were in stage IIIA and 21 in stage IIIB. Complete and partial responses were observed in 15 (25%) and 42 (70%) of the patients following four cycles of preoperative TEF chemotherapy regimen, respectively. Overall response was 95%, and primary lesion progressed only in 3 (5%) patients. The mean disease-free survival was 15.9 \u00b1 6.8 (range, 3.5\u201328) months and the mean overall survival was 18.6 \u00b1 7.2 (range, 5\u201330) months. The most frequent side effects were nausea-vomiting, mucositis, alopecia and leukopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TEF therapy is a treatment with a high overall response rate and toxicities similar to other taxotere combinations. A longer follow-up of patients is necessary for the determination of disease-free survival and overall survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089160208800608","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T05:34:16Z","timestamp":1523943256000},"page":"474-477","source":"Crossref","is-referenced-by-count":5,"title":["Neoadjuvant Chemotherapy with Taxotere-Epirubicin-5-Fluorouracil (TEF) in Local-Regionally Advanced Breast Cancer: A Preliminary Report"],"prefix":"10.1177","volume":"88","author":[{"given":"E\u015fmen","family":"Baltali","sequence":"first","affiliation":[{"name":"Hacettepe University Institute of Oncology, Department of Medical Oncology, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Kadri","family":"Altunda\u011f","sequence":"additional","affiliation":[{"name":"Hacettepe University Institute of Oncology, Department of Medical Oncology, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demir Ali","family":"Onat","sequence":"additional","affiliation":[{"name":"Hacettepe University Faculty of Medicine, Department of General Surgery, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"Abbaso\u011flu","sequence":"additional","affiliation":[{"name":"Hacettepe University Faculty of Medicine, Department of General Surgery, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yavuz","family":"\u00d6zi\u015fik","sequence":"additional","affiliation":[{"name":"Hacettepe University Institute of Oncology, Department of Medical Oncology, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nil\u00fcfer","family":"G\u00fcler","sequence":"additional","affiliation":[{"name":"Hacettepe University Institute of Oncology, Department of Medical Oncology, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lale","family":"Atahan","sequence":"additional","affiliation":[{"name":"Hacettepe University Institute of Oncology, Department of Radiation Oncology, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U\u011fur","family":"Berbero\u011flu","sequence":"additional","affiliation":[{"name":"Ankara Oncology Hospital, Department of General Surgey, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Altinok","sequence":"additional","affiliation":[{"name":"Ankara Oncology Hospital, Department of General Surgey, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismet","family":"Baran","sequence":"additional","affiliation":[{"name":"Ankara Social Security Hospital, Department of General Surgery, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130smail","family":"\u00c7elik","sequence":"additional","affiliation":[{"name":"Hacettepe University Institute of Oncology, Department of Medical Oncology, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fclten","family":"Tekuzman","sequence":"additional","affiliation":[{"name":"Hacettepe University Institute of Oncology, Department of Medical Oncology, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,11,1]]},"reference":[{"key":"bibr1-030089160208800608","first-page":"537","volume":"13","author":"Fisher B.","year":"1995","journal-title":"A model for studying the biology and therapy of primary breast cancer. 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