{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:03:32Z","timestamp":1777917812166,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aim and background<\/jats:title>\n                    <jats:p>To evaluate feasibility of neoadjuvant chemotherapy (NA-CT) followed by CT + radiotherapy (RT) in locally advanced or unresectable head and neck squamous cell carcinoma (HNSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      22 HNSCC patients were enrolled (18 males, 4 females; median age, 59.5 years; median ECOG PS, 1). Sites of disease: oral cavity, 18.2%; oropharynx, 40.9%; hypopharynx, 18.2%; larynx, 4.6%, multiple sites, 18.2%. T (tumor) category: T2, 13.6%; T3, 31.8%;T4, 54.5%. N (nodes) category: N0, 9.1%; N1, 18.1%; N2, 40.9%; N3, 31.8%. Stage: III, 4.6%; IVA, 63.6%; IVB, 31.8%. Induction carboplatin (AUC = 6) and paclitaxel (200 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) \u00d7 3 cycles (q21 days) were given. Responders received definitive radiotherapy with concurrent carboplatin (35 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      \/day from days 1 to 5 in weeks 1, 3, 5 and 7) and paclitaxel (50 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      on days 10, 24 and 38). Patients with node involvement were suggested to undergo postradiotherapy neck dissection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>NA-CT. 97% of planned chemotherapy cycles were administered. Prevalent toxicity was hematologic: 50% G4 neutropenia and 31.8% G3, one neutropenic fever. All patients had alopecia. Complete responses in T and N were 4 (18.2%) and 3 (15%), respectively. Partial responses were 13 (59%) and 9 (45%). There was 1 progressive disease. CT + RT. 79.9% of planned cycles of CT were administered. In 19 patients (86.4%) more than 50% of planned cycles of CT were completed. Median dose of RT was 70.2 Gy on T\/N+ and 54 Gy on N0. Limiting toxicity was mucositis in 77.3%, followed by neutropenia (59.1% G3\u2013G4). Median weight loss was 4.9%. 18.2% of patients required hospitalization. Complete responses in T and N were 15 (68.1%) and 8 (40%), respectively. Partial responses were 5 (22.7%) and 7 (35%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The preliminary results of this study are encouraging, despite the toxicity. Adequate follow-up is required to evaluate efficacy in terms of local-regional control and overall survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089160208800611","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T05:34:16Z","timestamp":1523943256000},"page":"489-494","source":"Crossref","is-referenced-by-count":6,"title":["Paclitaxel and Carboplatin in Neo-Adjuvant and Concomitant Chemoradiotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma"],"prefix":"10.1177","volume":"88","author":[{"given":"Gianni","family":"Fornari","sequence":"first","affiliation":[{"name":"Oncology Division, Ospedale Evangelico Valdese, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Artusio","sequence":"additional","affiliation":[{"name":"Oncology Division, Ospedale Evangelico Valdese, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenza","family":"Mairone","sequence":"additional","affiliation":[{"name":"Oncology Division, Ospedale Evangelico Valdese, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Airoldi","sequence":"additional","affiliation":[{"name":"Oncology Division, Ospedale S Giovanni Antica Sede, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Bongioannini","sequence":"additional","affiliation":[{"name":"ENT Unit, Ospedale Mauriziano and IRCC (Istituto per la Ricerca e la Cura del Cancro), Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrica","family":"Amasio","sequence":"additional","affiliation":[{"name":"ENT Unit, Ospedale Maria Vittoria, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Rosmino","sequence":"additional","affiliation":[{"name":"Radiotherapy Unit, Ospedale Mauriziano and JRCC (Istituto per la Ricerca e la Cura del Cancro) Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Gabriele","sequence":"additional","affiliation":[{"name":"Radiotherapy Unit, Ospedale Mauriziano and JRCC (Istituto per la Ricerca e la Cura del Cancro) Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,11,1]]},"reference":[{"key":"bibr1-030089160208800611","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106133242402"},{"key":"bibr2-030089160208800611","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)90011-4"},{"key":"bibr3-030089160208800611","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)90172-4"},{"key":"bibr4-030089160208800611","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011188726802"},{"issue":"8","key":"bibr5-030089160208800611","first-page":"116","volume":"5","author":"Airoldi 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