{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:06:31Z","timestamp":1777917991064,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and background<\/jats:title>\n                    <jats:p>Thyroid transcription factor (TTF-1) is a tissue-specific transcription factor expressed in the epithelial cells of thyroid and lung. The aim of this study was to evaluate the relationship between the expression of TTF-1 and clinicopathological parameters in pulmonary adenocarcinoma and adenosquamous carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Resection material of pneumonectomies and lobectomies of 39 patients was retrospectively examined. Twenty-eight patients were diagnosed with adenocarcinoma and 11 with adenosquamous carcinoma. Tumors were classified into 3 groups: a strongly positive group (++) with\n                      <jats:sup>\u2021<\/jats:sup>\n                      50% tumor cells positive for TTF-1; a weakly positive group (+) with 1\u201349% positive tumor cells; and a negative group (-) with less than 1% or no positive tumor cells. Analysis was performed with Kaplan-Meier estimates and log-rank tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Staining for TTF-1 was negative in 10 cases. There was focal staining in 9 cases, while there was diffuse staining in 20 (51%) cases out of 39, and 15 (75%) of these were adenocarcinomas. There was a statistically significant association between TTF-1 and lymph node metastases (P = 0.029). No relationship was found between TTF-1 positivity and disease-free and overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TTF-1 expression may be a predictor of lymph node metastases. Additional work in a larger group of patients is needed to better assess the utility of this marker.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089160609200411","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T05:47:43Z","timestamp":1523944063000},"page":"323-326","source":"Crossref","is-referenced-by-count":2,"title":["The Correlation between TTF-1 Immunoreactivity and the Occurrence of Lymph Node Metastases in Patients with Lung Cancer"],"prefix":"10.1177","volume":"92","author":[{"given":"Semsi","family":"Altaner","sequence":"first","affiliation":[{"name":"Department of Pathology, Trakya University, Edirne, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yener","family":"Yoruk","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Trakya University, Edirne, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fusun","family":"Tokatli","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine, Trakya University, Edirne, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zafer","family":"Ko\u00e7ak","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine, Trakya University, Edirne, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birsen","family":"Tosun","sequence":"additional","affiliation":[{"name":"Department of Pathology, Trakya University, Edirne, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Servet","family":"Guresci","sequence":"additional","affiliation":[{"name":"Department of Pathology, Trakya University, Edirne, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kemal","family":"Kutlu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Trakya University, Edirne, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,7,1]]},"reference":[{"key":"bibr1-030089160609200411","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.1.60"},{"key":"bibr2-030089160609200411","doi-asserted-by":"publisher","DOI":"10.1242\/dev.113.4.1093"},{"key":"bibr3-030089160609200411","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.12.6531"},{"key":"bibr4-030089160609200411","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.12.6881"},{"key":"bibr5-030089160609200411","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4781(96)00180-7"},{"key":"bibr6-030089160609200411","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.50.1.30"},{"key":"bibr7-030089160609200411","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.00801.x"},{"key":"bibr8-030089160609200411","first-page":"318","volume":"12","author":"Puglisi F.","year":"1999","journal-title":"Mod Pathol"},{"key":"bibr9-030089160609200411","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(00)00625-X"},{"key":"bibr10-030089160609200411","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200103000-00011"},{"key":"bibr11-030089160609200411","doi-asserted-by":"publisher","DOI":"10.1097\/00129039-200206000-00002"},{"key":"bibr12-030089160609200411","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.39.23139"},{"key":"bibr13-030089160609200411","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(03)00180-1"},{"key":"bibr14-030089160609200411","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-60049-4"},{"key":"bibr15-030089160609200411","first-page":"191","volume-title":"American Joint Committee on Cancer Staging Manual","author":"Greene F.L.","year":"2003"},{"key":"bibr16-030089160609200411","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"bibr17-030089160609200411","doi-asserted-by":"publisher","DOI":"10.1097\/00129039-200009000-00004"},{"key":"bibr18-030089160609200411","first-page":"119","volume-title":"Pathology of lung tumors","author":"Kerr K.M.","year":"1997"},{"key":"bibr19-030089160609200411","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1995.8080"},{"key":"bibr20-030089160609200411","doi-asserted-by":"publisher","DOI":"10.1042\/bj3190669"},{"key":"bibr21-030089160609200411","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.4.5933"},{"key":"bibr22-030089160609200411","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2003.18.4.494"},{"key":"bibr23-030089160609200411","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.9.4842"},{"key":"bibr24-030089160609200411","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(97)00092-0"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089160609200411","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089160609200411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:28:20Z","timestamp":1777660100000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030089160609200411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1177\/030089160609200411"],"URL":"https:\/\/doi.org\/10.1177\/030089160609200411","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}