{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:07:06Z","timestamp":1777918026215,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and background<\/jats:title>\n                    <jats:p>\n                      Mediastinal elective node irradiation (ENI) in patients with non-small cell lung cancer candidate to radical radiotherapy is controversial. In this study, the impact of co-registered [\n                      <jats:sup>18<\/jats:sup>\n                      F]fluorodeoxyglucose-positron emission tomography (PET) and standard computed tomography (CT) on definition of target volumes and toxicity parameters was evaluated, by comparison with standard CT-based simulation with and without ENI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      CT-based gross tumor volume (GTV\n                      <jats:sub>CT<\/jats:sub>\n                      ) was first contoured by a single observer without knowledge of PET results. Subsequently, the integrated GTV based on PET\/CT coregistered images (GTV\n                      <jats:sub>PET\/CT<\/jats:sub>\n                      ) was defined. Each patient was planned according to three different treatment techniques: 1) radiotherapy with ENI using the CT data set alone (ENI plan); 2) radiotherapy without ENI using the CT data set alone (no ENI plan); 3) radiotherapy without ENI using PET\/CT fusion data set (PET plan). Rival plans were compared for each patient with respect to dose to the normal tissues (spinal cord, healthy lungs, heart and esophagus).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The addition of PET-modified TNM staging in 10\/21 enrolled patients (48%); 3\/21 were shifted to palliative treatment due to detection of metastatic disease or large tumor not amenable to high-dose radiotherapy. In 7\/18 (39%) patients treated with radical radiotherapy, a significant (\u226525%) change in volume between GTV\n                      <jats:sub>CT<\/jats:sub>\n                      and GTV\n                      <jats:sub>PET\/CT<\/jats:sub>\n                      was observed. For all the organs at risk, ENI plans had dose values significantly greater than no-ENI and PET plans. Comparing no ENI and PET plans, no statistically significant difference was observed, except for maximum point dose to the spinal cord D\n                      <jats:sub>max<\/jats:sub>\n                      , which was significantly lower in PET plans. Notably, even in patients in whom PET\/CT planning resulted in an increased GTV, toxicity parameters were fairly acceptable, and always more favorable than with ENI plans.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our study suggests that [\n                      <jats:sup>18<\/jats:sup>\n                      F]-fluorodeoxyglucose-PET should be integrated in no-ENI techniques, as it improves target volume delineation without a major increase in predicted toxicity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089160709300116","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T03:50:41Z","timestamp":1519703441000},"page":"88-96","source":"Crossref","is-referenced-by-count":16,"title":["Role of Computed Tomographyand [\n                    <sup>18<\/sup>\n                    F] Fluorodeoxyglucose Positron Emission Tomography Image Fusion in Conformal Radiotherapy of Non-Small Cell Lung Cancer: A Comparison with Standard Techniques with and without Elective Nodal Irradiation"],"prefix":"10.1177","volume":"93","author":[{"given":"Giovanni Luca","family":"Ceresoli","sequence":"first","affiliation":[{"name":"Department of Oncology and Hematology, Istituto Clinico Humanitas, Rozzano (Milan);"},{"name":"Department of Oncology, and San Raffaele Scientific Institute, Milan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni Mauro","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, San Raffaele Scientific Institute, Milan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Castellone","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, San Raffaele Scientific Institute, Milan;"},{"name":"Department of Physics, University of Naples Federico II, Naples;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Rizzo","sequence":"additional","affiliation":[{"name":"IBFM-CNR, Institute for Molecular Bioimaging and Physiology, Segrate (Milan);"},{"name":"Department of Nuclear Medicine, San Raffaele Scientific Institute, Milan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Landoni","sequence":"additional","affiliation":[{"name":"IBFM-CNR, Institute for Molecular Bioimaging and Physiology, Segrate (Milan);"},{"name":"Department of Nuclear Medicine, San Raffaele Scientific Institute, Milan;"},{"name":"School of Medicine, University of Milan-Bicocca, Milan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanesa","family":"Gregorc","sequence":"additional","affiliation":[{"name":"Department of Oncology, and San Raffaele Scientific Institute, Milan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Calandrino","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, San Raffaele Scientific Institute, Milan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenio","family":"Villa","sequence":"additional","affiliation":[{"name":"Department of Oncology, and San Raffaele Scientific Institute, Milan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Messa","sequence":"additional","affiliation":[{"name":"IBFM-CNR, Institute for Molecular Bioimaging and Physiology, Segrate (Milan);"},{"name":"School of Medicine, University of Milan-Bicocca, Milan;"},{"name":"Department of Nuclear Medicine, HS Gerardo, Monza, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Santoro","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Istituto Clinico Humanitas, Rozzano (Milan);"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferruccio","family":"Fazio","sequence":"additional","affiliation":[{"name":"Department of Oncology, and San Raffaele Scientific Institute, Milan;"},{"name":"IBFM-CNR, Institute for Molecular Bioimaging and Physiology, Segrate (Milan);"},{"name":"Department of Nuclear Medicine, San Raffaele Scientific Institute, Milan;"},{"name":"School of Medicine, University of Milan-Bicocca, 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