{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:07:37Z","timestamp":1777918057478,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and background<\/jats:title>\n                    <jats:p>\n                      Neutron rays produce high linear energy transfer radiation, which has particular radiobiological characteristics. The aim of the study was to observe the curative effects and complications of external irradiation combined with californium-252 (\n                      <jats:sup>252<\/jats:sup>\n                      Cf) neutron intraluminal brachytherapy for treatment of cervical carcinoma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and study design<\/jats:title>\n                    <jats:p>\n                      From December 2000 to December 2004, 128 cases of cervical carcinoma staged IIA to IIIB were treated with\n                      <jats:sup>252<\/jats:sup>\n                      Cf neutron intraluminal brachytherapy using 8\u201310 Gy-eq per fraction, once a week. The total dose at reference point A was 36\u201340 Gy-eq in 4 to 5 fractions. From the second day after\n                      <jats:sup>252<\/jats:sup>\n                      Cf neutron intraluminal brachytherapy, the whole pelvic cavity was treated with 6 MV X-ray external irradiation, applying 2 Gy per fraction 4 times per week. After 20\u201324 Gy of external irradiation, the center of the whole pelvic field was blocked with a 4-cm-wide lead shield; the total dose of external irradiation was 44\u201350 Gy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The short-term curative effects were 95.3% complete remissions and 4.7% partial remissions. The 3-year and 5-year local control rates were 93.5% and 87.9%, respectively. The 3-year and 5-year survival rates were 87.5% and 70%, respectively. The rates of radiation complications were 4.7% for radiation cystitis, 7.8% for radiation proctitis, 6.3% for vaginal contracture and adhesion, and 5.5% for protracted radiation proctitis. The results of univariate and multivariate analysis indicated that differentiation of tumor cells and lymphatic metastasis are the main factors related to the clinical prognosis of cervical carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      A combination of external irradiation with\n                      <jats:sup>252<\/jats:sup>\n                      Cf neutron intraluminal brachytherapy for treatment of cervical carcinoma can be well tolerated by patients. The rate of local tumor control is high and radiation complications are few.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089160709300624","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T03:53:18Z","timestamp":1519703598000},"page":"636-640","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Report on External Irradiation Combined with Californium-252 Neutron Intraluminal Brachytherapy for Cervical Carcinoma Treatment"],"prefix":"10.1177","volume":"93","author":[{"given":"Huanyu","family":"Zhao","sequence":"first","affiliation":[{"name":"Tumor Hospital of Tianjin Medical University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keming","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Sun","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Geng","sequence":"additional","affiliation":[{"name":"Tumor Hospital of Tianjin Medical University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tumor Hospital of Tianjin Medical University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,11,1]]},"reference":[{"key":"bibr1-030089160709300624","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.137.3.6777827"},{"key":"bibr2-030089160709300624","first-page":"33","volume":"41","author":"Feola J.M.","year":"1980","journal-title":"Int J Radiat Biol"},{"key":"bibr3-030089160709300624","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8043(00)00214-1"},{"key":"bibr4-030089160709300624","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910915)68:6<1189::AID-CNCR2820680602>3.0.CO;2-F"},{"key":"bibr5-030089160709300624","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90467-A"},{"key":"bibr6-030089160709300624","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-199304000-00019"},{"key":"bibr7-030089160709300624","first-page":"253","volume":"170","author":"Maruyama Y.","year":"1994","journal-title":"Strahlenther Oncol"},{"key":"bibr8-030089160709300624","first-page":"742","volume":"36","author":"Luo G.","year":"2001","journal-title":"Chin J Obstet Gynecol"},{"key":"bibr9-030089160709300624","first-page":"302","volume":"17","author":"Wang Y.W.","year":"2003","journal-title":"J Prac Diagn Ther"},{"key":"bibr10-030089160709300624","first-page":"145","volume":"6","author":"Marjina L.A.","year":"1997","journal-title":"Chin J Radiat Oncol"},{"key":"bibr11-030089160709300624","first-page":"235","volume":"11","author":"Zhou C.H.","year":"2002","journal-title":"Chin J Radiat Oncol"},{"key":"bibr12-030089160709300624","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-003-1005-4"},{"key":"bibr13-030089160709300624","first-page":"208","volume":"2","author":"Zeng D.H.","year":"2005","journal-title":"Journal of Youjiang Nationalities Medical College"},{"key":"bibr14-030089160709300624","first-page":"273","volume":"13","author":"Wang P.","year":"2002","journal-title":"Foreign Medical Science (Section of Maternal and Child Health)"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089160709300624","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089160709300624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:29:48Z","timestamp":1777660188000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030089160709300624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["10.1177\/030089160709300624"],"URL":"https:\/\/doi.org\/10.1177\/030089160709300624","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}