{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:08:19Z","timestamp":1777918099446,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and background<\/jats:title>\n                    <jats:p>Little information is available on disease presentation and treatment outcome in very young patients with brain metastases from breast cancer. Therefore, we evaluated our results in this group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In our database, 7\/74 breast cancer patients treated for brain metastases were &lt;40 years old. All received whole-brain radiation therapy plus individual local or systemic measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In patients with information available, tumors were poorly differentiated and metastatic to the axillary lymph nodes at primary diagnosis. All patients had extracranial metastases. Two died from their brain disease within 5 months. Five patients died from extracranial progression after 3\u201384 months (2 long-term survivors beyond 2 years, characterized by single brain lesions and high performance status).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Very young patients did not achieve a better outcome than intermediate age groups. Whole-brain radiation therapy plus surgery or radiosurgery provided durable CNS control in most of the patients. Improved systemic therapy appears to represent the key to a better outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089160809400508","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T04:02:47Z","timestamp":1519704167000},"page":"691-693","source":"Crossref","is-referenced-by-count":0,"title":["Disease Presentation and Outcome in Very Young Patients with Brain Metastases from Breast Cancer"],"prefix":"10.1177","volume":"94","author":[{"given":"Carsten","family":"Nieder","sequence":"first","affiliation":[{"name":"Radiation Oncology Unit, Nordlandssykehuset HF, Bod\u00f8, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina T","family":"Astner","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Klinikum rechts der Isar der Technischen Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolaus H","family":"Andratschke","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Klinikum rechts der Isar der Technischen Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Klinikum rechts der Isar der Technischen Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"bibr1-030089160809400508","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.6185"},{"key":"bibr2-030089160809400508","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(96)00619-0"},{"key":"bibr3-030089160809400508","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02967-X"},{"key":"bibr4-030089160809400508","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2006.08.001"},{"key":"bibr5-030089160809400508","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2005.06.004"},{"key":"bibr6-030089160809400508","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(88)80199-0"},{"key":"bibr7-030089160809400508","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22041"},{"key":"bibr8-030089160809400508","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2004.03.012"},{"key":"bibr9-030089160809400508","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-7-53"},{"key":"bibr10-030089160809400508","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(98)00421-3"},{"key":"bibr11-030089160809400508","first-page":"88","volume":"6","author":"Amendola B.E.","year":"2000","journal-title":"Cancer J"},{"key":"bibr12-030089160809400508","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-000-0333-1"},{"key":"bibr13-030089160809400508","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20167"},{"key":"bibr14-030089160809400508","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-007-9420-5"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089160809400508","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089160809400508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:30:45Z","timestamp":1777660245000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030089160809400508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["10.1177\/030089160809400508"],"URL":"https:\/\/doi.org\/10.1177\/030089160809400508","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}