{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:15:30Z","timestamp":1782940530820,"version":"3.54.5"},"reference-count":37,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and Background<\/jats:title>\n                    <jats:p>Recent publications of breast cancer classification based on gene expression profile analyses indicate that medullary breast carcinomas (MBC) may be considered part of the basal-like carcinoma spectrum made up of ER-negative, PR-negative and HER-2-negative cells (\u201ctriple-negative phenotype\u201d). On the other hand, there are also data showing that a proportion of MBC and atypical MBC (AMBC) is ER, PR and\/or HER-2 positive. Therefore, we have decided to immunohistochemically analyze ER, PR, HER-2 and basal\/myoepithelial markers CK5\/6, p63 and EGFR expression in our archival paraffin-embedded MBC and AMBC samples from 48 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Immunohistochemical evaluation of samples which were derived from patients operated on at our two hospitals between 1999 and 2005.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Typical MBC was found in 39 patients and AMBC in 9 patients. The patients ranged in age from 32 to 84 years (median 55). Modified radical mastectomy with axillary dissection was performed in 30\/48 patients (63%) while breast segmentectomy with axillary dissection was performed in 18\/48 patients (37%). Metastases in axillary lymph nodes were observed in 15\/48 patients (31%). ER positivity was present in 3\/48 patients (6%), PR positivity in 8\/48 (17%), and a positive HER-2 reaction was present in 14\/48 patients (29%). CK 5\/6 was positive in 20\/48, p63 in 24\/48 and EGFR in 8\/48 patients. Adjuvant therapy was applied in all but 2 patients. Alive were 45\/48 (94%) of patients. With the exception of PR expression, 39 patients with typical MBC and 9 patients with AMBC were comparable in the analyzed parameters. Positive HER-2 antigen expression in the analyzed sample was not found to be associated to a statistically significant degree with the MBC or AMBC histological tumor type, tumor size, axillary lymph node metastases, ER and PR status nor with patient survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The data from our study seem to be generally comparable with the relatively scarce published data on clinicopathological parameters of MBC and AMBC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089160809400611","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T04:00:39Z","timestamp":1519704039000},"page":"838-844","source":"Crossref","is-referenced-by-count":22,"title":["Immunohistochemical Analysis of ER, PR, HER-2, CK 5\/6, p63 and EGFR Antigen Expression in Medullary Breast Cancer"],"prefix":"10.1177","volume":"94","author":[{"given":"Bozica","family":"Matkovic","sequence":"first","affiliation":[{"name":"University Hospital for Tumors, Zagreb"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Juretic","sequence":"additional","affiliation":[{"name":"Zagreb University Hospital Center, Zagreb"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Separovic","sequence":"additional","affiliation":[{"name":"University Hospital for Tumors, Zagreb"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Novosel","sequence":"additional","affiliation":[{"name":"University Hospital for Tumors, Zagreb"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Separovic","sequence":"additional","affiliation":[{"name":"University Hospital for Tumors, Zagreb"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Gamulin","sequence":"additional","affiliation":[{"name":"Zagreb University Hospital Center, Zagreb"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bozo","family":"Kruslin","sequence":"additional","affiliation":[{"name":"University Hospital \u201cSisters of Mercy\u201d, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"bibr1-030089160809400611","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm271"},{"key":"bibr2-030089160809400611","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026439204849"},{"key":"bibr3-030089160809400611","unstructured":"National Cancer Institute: Breast cancer treatment (PDQ). 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