{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:08:36Z","timestamp":1777918116809,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and Background<\/jats:title>\n                    <jats:p>Advanced chemorefractory epithelial thymic tumors are still a challenge in clinical oncology. A therapeutic approach targeting a key molecular pathway could be the ideal solution in a neoplasm that can overexpress epidermal growth factor receptor (EGFR) in the epithelial component.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A patient with metastatic heavily pretreated thymic carcinoma was evaluated for EGFR expression in the primary tumor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Strong EGFR expression was revealed by immunohistochemistry. The patient received erlotinib therapy but had obtained no response after four months of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This preliminary experience suggests that erlotinib may not be a useful therapeutic choice in advanced pretreated thymic carcinomas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089160809400613","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T04:00:39Z","timestamp":1519704039000},"page":"849-852","source":"Crossref","is-referenced-by-count":13,"title":["Erlotinib in Advanced Well-Differentiated Thymic Carcinoma with Overexpression of EGFR: A Case Report"],"prefix":"10.1177","volume":"94","author":[{"given":"Rebecca","family":"Pedersini","sequence":"first","affiliation":[{"name":"Division of Medical Oncology, Central Hospital, Bolzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Vattemi","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Central Hospital, Bolzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rita","family":"Lusso","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Central Hospital, Bolzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Mazzoleni","sequence":"additional","affiliation":[{"name":"Division of Pathology, Central Hospital, Bolzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinrich","family":"Ebner","sequence":"additional","affiliation":[{"name":"Division of Vascular and Thoracic Surgery, Central Hospital, Bolzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Graiff","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, 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