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Therapy-related acute myeloid leukemia (AML), however, has been rarely reported in esophageal cancer patients receiving CCRT. We here report two such cases. One patient received neoadjuvant CCRT and developed AML with a complex chromosome aberration 55 months after exposure to radiation- and cisplatin-based chemotherapy. The other had AML with t(8;21) twenty months following CCRT as definitive therapy. Such a severe complication of CCRT is a serious concern in esophageal cancer treatment. In the wake of the prolonged survival of some esophageal cancer patients, the treatment intensity may need to be reconsidered according to such experience.<\/jats:p>","DOI":"10.1177\/030089160909500317","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T04:04:51Z","timestamp":1519704291000},"page":"371-373","source":"Crossref","is-referenced-by-count":10,"title":["Therapy-Related Acute Myeloid Leukemia after Concurrent Chemoradiotherapy for Esophageal Cancer: Report of Two Cases"],"prefix":"10.1177","volume":"95","author":[{"given":"Hung","family":"Chang","sequence":"first","affiliation":[{"name":"Division of Hematology-Oncology, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang Chi","family":"Liaw","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsien Kun","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"bibr1-030089160909500317","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.0881"},{"key":"bibr2-030089160909500317","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1177\/030089169808400226","volume":"84","author":"Tordiglione M.","year":"1998","journal-title":"Tumori"},{"key":"bibr3-030089160909500317","doi-asserted-by":"publisher","DOI":"10.1080\/028418601750444088"},{"key":"bibr4-030089160909500317","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.1.156"},{"key":"bibr5-030089160909500317","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.17.1623"},{"key":"bibr6-030089160909500317","doi-asserted-by":"publisher","DOI":"10.3109\/10428199309054725"},{"key":"bibr7-030089160909500317","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1182\/blood.V65.6.1364.bloodjournal6561364","volume":"65","author":"Michels S.D.","year":"1985","journal-title":"Blood"},{"key":"bibr8-030089160909500317","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199902043400504"},{"key":"bibr9-030089160909500317","first-page":"30","volume":"139","author":"Mendoza E.A.","year":"1987","journal-title":"J La State Med Soc"},{"key":"bibr10-030089160909500317","first-page":"415","volume":"37","author":"Fukunishi K.","year":"1999","journal-title":"Nihon Kokyuki Gakkai Zasshi"},{"key":"bibr11-030089160909500317","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2005.03838.x"},{"key":"bibr12-030089160909500317","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200363150-00004"},{"issue":"9","key":"bibr13-030089160909500317","doi-asserted-by":"crossref","first-page":"ix71","DOI":"10.1093\/annonc\/mdm297","volume":"18","author":"Diehl V.","year":"2007","journal-title":"Ann Oncol"},{"key":"bibr14-030089160909500317","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.12.2370"},{"key":"bibr15-030089160909500317","doi-asserted-by":"publisher","DOI":"10.1007\/s002770100378"},{"key":"bibr16-030089160909500317","first-page":"875","volume":"87","author":"Kamai T.","year":"1996","journal-title":"Nippon Hinyokika Gakkai Zasshi"},{"key":"bibr17-030089160909500317","first-page":"448","volume":"37","author":"Miyata A.","year":"1996","journal-title":"Rinsho Ketsueki"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089160909500317","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089160909500317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:32:46Z","timestamp":1777660366000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030089160909500317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["10.1177\/030089160909500317"],"URL":"https:\/\/doi.org\/10.1177\/030089160909500317","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}