{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:27:26Z","timestamp":1792146446656,"version":"4.4.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:p>Familial adenomatous polyposis is an inherited disorder characterized by the development of hundreds of colorectal adenomas during adolescence, which in many cases will transform into colorectal cancer by the fourth decade of life, along with the development of various malignant tumors including hepatoblastoma. We report on a female patient with a de novo interstitial deletion of 5q21.3-q23.3, encompassing the APC gene, associated with adenomatous polyposis and early colorectal cancer, hepatoblastoma, epidermoid cysts, mental retardation, several mild dysmorphic signs and lower limb venous thrombosis.<\/jats:p>","DOI":"10.1177\/030089160909500629","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T04:10:27Z","timestamp":1519704627000},"page":"819-822","source":"Crossref","is-referenced-by-count":7,"title":["Could APC Gene Screening be Useful in Children with Hepatoblastoma? Early Onset of Adenocarcinoma in a Child with Familial Adenomatous Polyposis and Hepatoblastoma"],"prefix":"10.1177","volume":"95","author":[{"given":"Ilaria","family":"Lazzareschi","sequence":"first","affiliation":[{"name":"Division of Pediatric Oncology, A Gemelli Hospital, Catholic University of Rome, Rome, Italy"},{"name":"Ilaria Lazzareschi and Giuseppe Barone have contributed equally to this work."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Barone","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, A Gemelli Hospital, Catholic University of Rome, Rome, Italy"},{"name":"Ilaria Lazzareschi and Giuseppe Barone have contributed equally to this work."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Mastrangelo","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, A Gemelli Hospital, Catholic University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria Francesca","family":"Furfaro","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, A Gemelli Hospital, Catholic University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Rando","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, A Gemelli Hospital, Catholic University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Riccardi","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, A Gemelli Hospital, Catholic University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"bibr1-030089160909500629","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012330626600"},{"key":"bibr2-030089160909500629","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.5.742"},{"key":"bibr3-030089160909500629","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.4.515"},{"key":"bibr4-030089160909500629","doi-asserted-by":"publisher","DOI":"10.1126\/science.1651563"},{"key":"bibr5-030089160909500629","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.3.417"},{"key":"bibr6-030089160909500629","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320430621"},{"key":"bibr7-030089160909500629","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.26.1.61"},{"key":"bibr8-030089160909500629","first-page":"5007","volume":"55","author":"Kurahashi H.","year":"1995","journal-title":"Cancer Res"},{"key":"bibr9-030089160909500629","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20698"},{"key":"bibr10-030089160909500629","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318174e808"},{"key":"bibr11-030089160909500629","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50044"},{"key":"bibr12-030089160909500629","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.04674.x"},{"key":"bibr13-030089160909500629","doi-asserted-by":"publisher","DOI":"10.1086\/301634"},{"key":"bibr14-030089160909500629","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30421"},{"key":"bibr15-030089160909500629","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320250309"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089160909500629","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089160909500629","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:33:24Z","timestamp":1777660404000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030089160909500629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.1177\/030089160909500629"],"URL":"https:\/\/doi.org\/10.1177\/030089160909500629","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}