{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:49:20Z","timestamp":1790470160582,"version":"4.1.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and Background<\/jats:title>\n                    <jats:p>Studies reporting activated Wnt signaling in all stages of chronic myeloid leukemia (CML) have demonstrated that deregulation of the pathway plays a role in the pathogenesis of this disease. Several reports have suggested mechanisms for the deregulated Wnt signaling and beta-catenin stabilization observed in CML. One possible mechanism for beta-catenin stabilization could be the acquisition of mutations at its N-terminal domain, especially in the third exon where it is marked via phosphorylation for degradation. We sought to determine whether mutations in the third exon of the beta-catenin gene are responsible for the observed Wnt activation in CML<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>We screened bone marrow specimens from 33 patients with CML in the chronic phase and also examined the K562 cell line for beta-catenin mutations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>None of the patients nor the K562 cell line were found to carry mutations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Beta-catenin amino-terminal mutations are not observed or very rare and therefore are not the underlying mechanism of activated Wnt signaling in CML.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089160909500633","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T04:10:27Z","timestamp":1519704627000},"page":"836-839","source":"Crossref","is-referenced-by-count":8,"title":["Beta-Catenin Mutations are not Observed in Chronic Myeloid Leukemia"],"prefix":"10.1177","volume":"95","author":[{"given":"Zeynep","family":"Sercan","sequence":"first","affiliation":[{"name":"Department of Medical Biology and Genetics, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melek","family":"Pehlivan","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Genetics, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Gokturk","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Genetics, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakki Ogun","family":"Sercan","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Genetics, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"bibr1-030089160909500633","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0140-6736(07)61165-9","volume":"370","author":"Hehlman R.","year":"2007","journal-title":"Lancet"},{"key":"bibr2-030089160909500633","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2147"},{"key":"bibr3-030089160909500633","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2007.01.023"},{"key":"bibr4-030089160909500633","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2003.10.001"},{"key":"bibr5-030089160909500633","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2400751"},{"key":"bibr6-030089160909500633","doi-asserted-by":"publisher","DOI":"10.1038\/nri1529"},{"key":"bibr7-030089160909500633","doi-asserted-by":"publisher","DOI":"10.1038\/nature01593"},{"key":"bibr8-030089160909500633","doi-asserted-by":"publisher","DOI":"10.1097\/01.moh.0000133649.61121.ec"},{"key":"bibr9-030089160909500633","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.20.010403.113126"},{"key":"bibr10-030089160909500633","doi-asserted-by":"publisher","DOI":"10.1080\/08977190500125746"},{"key":"bibr11-030089160909500633","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1101\/gad.14.15.1837","volume":"14","author":"Polakis P.","year":"2000","journal-title":"Genes Dev"},{"key":"bibr12-030089160909500633","first-page":"761","volume":"21","author":"Khan N.I.","year":"2006","journal-title":"Histol Histopathol"},{"key":"bibr13-030089160909500633","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5307.1787"},{"key":"bibr14-030089160909500633","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5307.1790"},{"key":"bibr15-030089160909500633","doi-asserted-by":"publisher","DOI":"10.1101\/gad.230302"},{"key":"bibr16-030089160909500633","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040258"},{"key":"bibr17-030089160909500633","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510423103"},{"key":"bibr18-030089160909500633","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400536"},{"key":"bibr19-030089160909500633","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601485"},{"key":"bibr20-030089160909500633","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.11.003"},{"key":"bibr21-030089160909500633","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404657"},{"key":"bibr22-030089160909500633","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780199638420.001.0001","volume-title":"Human cytogenetics: a practical approach: malignancy and acquired abnormalities","author":"Rooney D.E.","year":"2001","edition":"3"},{"key":"bibr23-030089160909500633","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2005.04.011"},{"key":"bibr24-030089160909500633","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.5745"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089160909500633","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089160909500633","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:33:25Z","timestamp":1777660405000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030089160909500633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.1177\/030089160909500633"],"URL":"https:\/\/doi.org\/10.1177\/030089160909500633","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}