{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:37:49Z","timestamp":1787769469435,"version":"build-2784847793"},"reference-count":19,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To determine the feasibility and efficacy of stereotactic body radiotherapy (SBRT) for huge hepatocellular carcinoma unsuitable for other therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Six patients with very large hepatocellular carcinomas (&gt;10 cm) unsuitable for surgical resection or that failed to respond to transcatheter arterial chemoembolization (TACE) were treated by SBRT. Doses ranged from 32 Gy to 40 Gy in four fractions. Survival, response, and toxicities were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After a median follow-up of 25.9 months (range 8.1-56 months), three patients had died and three were alive. Overall, treatment was well tolerated and no dose-limiting toxicity or radiation-induced liver disease was observed. The median survival was 10 months (range 3\u201356 months) and the median progression-free duration was 6 months (range, 2\u201321 months). Partial response was achieved by four patients, stable disease by one, and one patient had disease progression. One patient with a partial response who underwent lobectomy after SBRT was alive 56 months post-SBRT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study suggests that SBRT can be delivered safely at 32\u201340 Gy in four fractions to huge hepatocellular carcinoma. Furthermore, combinations of SBRT with other modalities such as surgery or TACE might prolong survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089161009600111","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T04:08:25Z","timestamp":1519704505000},"page":"65-70","source":"Crossref","is-referenced-by-count":16,"title":["Pilot Study of Stereotactic Body Radiotherapy for Huge Hepatocellular Carcinoma Unsuitable for Other Therapies"],"prefix":"10.1177","volume":"96","author":[{"given":"Young-Joo","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Sook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Yul","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul Koo","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Seok","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-kyu","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Cheol","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul Ju","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Beom","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byong Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Han","family":"Lee","sequence":"additional","affiliation":[{"name":"Cyberknife Center, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"bibr1-030089161009600111","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.55.2.74"},{"key":"bibr2-030089161009600111","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199304000-00009"},{"key":"bibr3-030089161009600111","first-page":"757","volume":"48","author":"Abdel-Wahab 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