{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:11:12Z","timestamp":1777918272332,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and background<\/jats:title>\n                    <jats:p>\n                      Thymic tumors (thymomas and thymic carcinomas) represent 50% of all mediastinal tumors. Thymomas usually express high levels of somatostatin receptors, which enable in vivo imaging with\n                      <jats:sup>111<\/jats:sup>\n                      In-DTPA-octreotide (OctreoScan\u00ae). The aim of this study was to further investigate the role of radionuclide techniques in the diagnosis, staging and follow-up of these tumors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eight patients (5 women, 3 men, age range 35\u201379 years; mean \u00b1 SD 56.1 \u00b1 15.8 years) entered the study. In 4 patients, myasthenia gravis was the presenting symptom.\n                      <jats:sup>111<\/jats:sup>\n                      In-DTPA-octreotide scan was performed within 3 weeks after contrast enhanced CT and\/or MRI. Planar and tomographic images were acquired within 24 hours of the injection of 111 MBq OctreoScan. The scintigraphic results were defined in correlation with the histological findings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Histology revealed thymoma in 3 patients, thymic carcinoma in 1, insular carcinoma of presumably thymic origin in 1, thymic carcinoid in 1, and thymic hyperplasia in 2 patients. Two thymomas were at stage I, 1 thymoma and 1 thymic carcinoma at stage II, 1 insular carcinoma of presumably thymic origin at stage IV, and 1 thymic carcinoid at stage IV. OctreoScan consistently accumulated in primary and\/or metastatic sites of thymic tumors while no radiotracer uptake was detected in the 2 patients with benign thymic hyperplasia. In 1 patient with a very large mediastinal mass (13 cm in largest diameter) and multiple metastatic deposits in the lungs, OctreoScan scintigraphy showed a large area of pathological uptake in the anterior mediastinum and a small area of focal uptake in the cervical-dorsal region of the right lung corresponding to a lymph node expressing somatostatin receptors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>OctreoScan is avidly taken up by thymic tumors, enabling the diagnosis of these tumors and a better evaluation of their extension. It does not accumulate in thymic hyperplasia, thus allowing the differential diagnosis between these 2 pathological conditions. In patients affected by myasthenia gravis, OctreoScan scintigraphy can play an important role in characterizing thymic masses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089161109700210","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T04:17:08Z","timestamp":1519705028000},"page":"191-195","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Current Role of\n                    <sup>111<\/sup>\n                    In-DTPA-Octreotide Scintigraphy in Diagnosis of Thymic Masses"],"prefix":"10.1177","volume":"97","author":[{"given":"Federica","family":"Guidoccio","sequence":"first","affiliation":[{"name":"Regional Center of Nuclear Medicine, University of Pisa, Pisa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariano","family":"Grosso","sequence":"additional","affiliation":[{"name":"Regional Center of Nuclear Medicine, University of Pisa, Pisa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Maccauro","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Orsini","sequence":"additional","affiliation":[{"name":"Regional Center of Nuclear Medicine, University of Pisa, Pisa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzio","family":"Perri","sequence":"additional","affiliation":[{"name":"Regional Center of Nuclear Medicine, University of Pisa, Pisa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Boni","sequence":"additional","affiliation":[{"name":"Regional Center of Nuclear Medicine, University of Pisa, Pisa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Banti","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Medical Physics, Radiology, PET\/CT Center, Santa Maria della Misericordia Hospital, Rovigo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaia","family":"Grassetto","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Medical Physics, Radiology, PET\/CT Center, Santa Maria della Misericordia Hospital, Rovigo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Rubello","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Medical Physics, Radiology, PET\/CT Center, Santa Maria della Misericordia Hospital, Rovigo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliano","family":"Mariani","sequence":"additional","affiliation":[{"name":"Regional Center of Nuclear Medicine, University of Pisa, Pisa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duccio","family":"Volterrani","sequence":"additional","affiliation":[{"name":"Regional Center of Nuclear Medicine, University of Pisa, 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