{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:11:05Z","timestamp":1777918265329,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:p>\n                    We describe the case of a squamous cell carcinoma spreading to the skin and regional lymph nodes from the umbilicus. Bilateral inguinal lymphadenectomy and a session of electrochemotherapy with bleomycin 15 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    were performed. However, because of the development of new cutaneous nodules in the abdominopelvic region, we performed targeted palliative therapy with erlotinib 150 mg\/day. Targeted adjuvant therapy was preferred to the use of a major cytotoxic agent because of the high risk of superinfection and heart failure. Erlotinib produced a partial clinical response with reduction of the number and size of the skin nodules. CT scan performed after 60 days of treatment did not show any new lesions.\n                  <\/jats:p>\n                  <jats:p>To our knowledge, this is the first report of an umbilical metastatic squamous cell carcinoma treated with modern targeted therapy. This therapeutic strategy can be considered a valid palliative option in the management of metastatic cutaneous nodules of this rare primary site.<\/jats:p>","DOI":"10.1177\/030089161109700219","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T04:17:08Z","timestamp":1519705028000},"page":"236-238","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Squamous Cell Carcinoma of the Umbilicus: Management of an Unusual Localization"],"prefix":"10.1177","volume":"97","author":[{"given":"Giuseppe","family":"Macrip\u00f2","sequence":"first","affiliation":[{"name":"Department of Oncology and Hematology, Dermatologic Surgery, AOU San Giovanni Battista-Molinette, Ospedale San Lazzaro, Turin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Caliendo","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Dermatologic Surgery, AOU San Giovanni Battista-Molinette, Ospedale San Lazzaro, Turin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcella","family":"Grassi","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Dermatologic Surgery, AOU San Giovanni Battista-Molinette, Ospedale San Lazzaro, Turin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Lista","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Section of Medical Oncology, Centro Oncologico Subalpino (COES), AOU San Giovanni Battista-Molinette, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Ribero","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Dermatologic Surgery, AOU San Giovanni Battista-Molinette, Ospedale San Lazzaro, Turin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Giacone","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Dermatologic Surgery, AOU San Giovanni Battista-Molinette, Ospedale San Lazzaro, Turin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrica","family":"Milanese","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Section of Medical Oncology, Centro Oncologico Subalpino (COES), AOU San Giovanni Battista-Molinette, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libero","family":"Ciuffreda","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Section of Medical Oncology, Centro Oncologico Subalpino (COES), AOU San Giovanni Battista-Molinette, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"bibr1-030089161109700219","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70002-Y"},{"key":"bibr2-030089161109700219","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-3-13"},{"key":"bibr3-030089161109700219","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2001.00857-4.x"},{"key":"bibr4-030089161109700219","doi-asserted-by":"publisher","DOI":"10.1177\/000313480707300921"},{"key":"bibr5-030089161109700219","doi-asserted-by":"publisher","DOI":"10.1097\/00042728-200304000-00016"},{"key":"bibr6-030089161109700219","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-9976-0"},{"key":"bibr7-030089161109700219","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.6.5.671"},{"key":"bibr8-030089161109700219","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2008.117"},{"key":"bibr9-030089161109700219","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21512"},{"key":"bibr10-030089161109700219","first-page":"581","volume":"18","author":"Hermanns J.F.","year":"2007","journal-title":"Oncol Rep"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089161109700219","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089161109700219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:34:56Z","timestamp":1777660496000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030089161109700219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.1177\/030089161109700219"],"URL":"https:\/\/doi.org\/10.1177\/030089161109700219","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}