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Sorafenib is generally well tolerated and has an acceptable toxicity profile. Gastrointestinal perforation is a rare adverse event. We present a case of transverse colon perforation during sorafenib therapy for advanced HCC. A 68-year-old woman with advanced HCC was treated with sorafenib. Eight weeks later the patient presented with the sudden onset of sharp abdominal pain. Emergency surgery was performed for panperitonitis and a perforation involving the transverse colon.<\/jats:p>","DOI":"10.1177\/030089161109700618","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T04:23:29Z","timestamp":1519705409000},"page":"794-799","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Colon Perforation during Sorafenib Therapy for Advanced Hepatocelluar Carcinoma. 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