{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:11:55Z","timestamp":1777918315479,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and Background<\/jats:title>\n                    <jats:p>Esophageal cancer patients with pathologic lymph node involvement generally have a poor prognosis. Many randomized controlled trials have not achieved consistent results similar to those of the RTOG8501 trial, and the long-term survival rate has not increased. The present study aimed to compare the efficacy and toxic side effects of concurrent chemoradiotherapy and radiotherapy alone to treat N1 esophageal carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Study Design<\/jats:title>\n                    <jats:p>\n                      A total of 130 N1 esophageal carcinoma patients were enrolled and randomly divided into two groups: concurrent chemoradiotherapy group (n = 65) and radiotherapy group (n = 65). Both groups received three-dimensional conformal radiotherapy with a total dose of 64\u201366 Gy. Meanwhile, to the concurrent chemoradiotherapy group, an additional chemotherapy protocol (nedaplatin, 20 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      \/d, 5-FU, 500 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      \/d for four days) was given from day 1, and such treatment was repeated until day 29. From day 21 after radiotherapy, two cycles of a consolidated chemotherapy protocol were given at an interval of 28 days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The survival rates at one, two, and three years were 72.3%, 55.3%, and 40% in the concurrent chemoradiotherapy group, respectively, and 75.3%, 38.5%, and 18.5% in the radiotheray group (P = 0.007), respectively. The survival rates of the patients in the concurrent chemoradiotherapy group who completed one to two cycles and three to four cycles at one, two, and three years were 70%, 53.3%, and 30%, and 74.2%, 57.1%, 48.6% (P = 0.128), respectively. Three-year distant metastasis rates were 10.7% in the concurrent chemoradiotherapy group and 16.9% in the radiotherapy group. Acute toxicity in the concurrent chemoradiotherapy group was higher than in the radiotherapy group. Late toxic side effects were similar in the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared with radiotherapy alone, concurrent chemoradiotherapy in the treatment of esophageal carcinoma with local lymph node enlargement can improve the three-year survival rate. Moreover, completion of three to four cycles of chemotherapy may have better efficacy than one to two cycles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089161209800108","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T04:28:04Z","timestamp":1519705684000},"page":"60-65","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinical Study of Concurrent Chemoradiotherapy or Radiotherapy Alone for Esophageal Cancer Patients with Positive Lymph Node Metastasis"],"prefix":"10.1177","volume":"98","author":[{"given":"Jihua","family":"Han","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, First Hospital of Huaian, Nanjing Medical University, Huaian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiguo","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, First Hospital of Huaian, Nanjing Medical University, Huaian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changhua","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, First Hospital of Huaian, Nanjing Medical University, Huaian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xilei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, First Hospital of Huaian, Nanjing Medical University, Huaian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, First Hospital of Huaian, Nanjing Medical University, Huaian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoye","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, First Hospital of Huaian, Nanjing Medical University, 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