{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:11:55Z","timestamp":1777918315541,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the impact of tomotherapy on the dose delivered to the lungs and other normal tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>From February 2008 to May 2009, 35 patients with stage IIIA\/IIIB non-small cell lung cancer were treated with helical tomotherapy at the S. Camillo-Forlanini Hospital. For our study we selected 20 patients who underwent chemotherapy followed by sequential radiotherapy. The planning target volume was delineated using planning CT scan and FDG-PET. The mean prescribed radiation dose was 67.5 Gy delivered in 30 fractions at a dose of 2.25 Gy per fraction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median follow-up was 12.3 months. All patients developed acute esophageal toxicity, 15 of RTOG grade 1 and 5 of RTOG grade 2. At first follow-up 15 patients presented stable disease or partial response, 4 patients presented complete response, and 1 patient presented disease progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Helical tomotherapy is useful to achieve dose-per-fraction escalation without increasing the treatment-related morbidity. Our results applying dose escalation were encouraging considering that we delivered doses that may be difficult to achieve with 3-dimensional treatments with no excessive complication rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089161209800111","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T04:28:04Z","timestamp":1519705684000},"page":"86-89","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Radiotherapy for Inoperable Non-Small Cell Lung Cancer using Helical Tomotherapy"],"prefix":"10.1177","volume":"98","author":[{"given":"Alessia","family":"Monaco","sequence":"first","affiliation":[{"name":"Department of Radiotherapy, S. Camillo-Forlanini Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Caruso","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, S. Camillo-Forlanini Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Giammarino","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, S. Camillo-Forlanini Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Cianciulli","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, S. Camillo-Forlanini Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina","family":"Pressello","sequence":"additional","affiliation":[{"name":"Department of Health Physics, S. Camillo-Forlanini Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Donato","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, S. Camillo-Forlanini Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"bibr1-030089161209800111","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/83.6.417"},{"key":"bibr2-030089161209800111","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(91)90131-M"},{"key":"bibr3-030089161209800111","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90238-Q"},{"key":"bibr4-030089161209800111","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-4296(99)80058-7"},{"key":"bibr5-030089161209800111","doi-asserted-by":"publisher","DOI":"10.1118\/1.596958"},{"key":"bibr6-030089161209800111","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)01374-2"},{"key":"bibr7-030089161209800111","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)90206-7"},{"issue":"1","key":"bibr8-030089161209800111","first-page":"S76","volume":"48","author":"Aldridge J.S.","year":"1998","journal-title":"Radiother Oncol"},{"key":"bibr9-030089161209800111","doi-asserted-by":"publisher","DOI":"10.1177\/030089169908500305"},{"key":"bibr10-030089161209800111","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)01809-0"},{"key":"bibr11-030089161209800111","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)04389-4"},{"key":"bibr12-030089161209800111","first-page":"1938","volume":"30","author":"Kron T.","year":"2003","journal-title":"Med Phys"},{"key":"bibr13-030089161209800111","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.04.021"},{"key":"bibr14-030089161209800111","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.09.046"},{"key":"bibr15-030089161209800111","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.11.012"},{"key":"bibr16-030089161209800111","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-200302000-00014"},{"key":"bibr17-030089161209800111","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(86)90061-1"},{"key":"bibr18-030089161209800111","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)06305-8"},{"key":"bibr19-030089161209800111","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.2.358"},{"key":"bibr20-030089161209800111","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(97)00079-0"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089161209800111","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089161209800111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:35:53Z","timestamp":1777660553000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030089161209800111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1177\/030089161209800111"],"URL":"https:\/\/doi.org\/10.1177\/030089161209800111","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}