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Phase III trials in patients with advanced HCC treated with sorafenib (SO), a multitargeted tyrosine kinase inhibitor, showed significant improvements in both overall and progression-free survival. We report the cases of two elderly patients with advanced HCC who had prolonged stable disease following treatment with SO (400 mg bid). Patient 1 was treated with SO for a period of 16 months until evidence of right sacral metastases was noted. Patient 2 received SO 400 mg bid from January 2009 to October 2009 until radiological evidence of disease progression was noted. Both patients experienced minimal toxicity, suggesting that SO can be safely administered to elderly patients.<\/jats:p>","DOI":"10.1177\/030089161209800224","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T04:31:01Z","timestamp":1519705861000},"page":"e53-e56","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Response after Sorafenib for Hepatocellular Carcinoma in Elderly Patients: A Report of Two Cases"],"prefix":"10.1177","volume":"98","author":[{"given":"Francesca","family":"Spada","sequence":"first","affiliation":[{"name":"Department of Medicine, Upper Gastro-Intestinal Tract and Neuroendocrine Tumors Unit, European Institute of Oncology, Milan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Squadroni","sequence":"additional","affiliation":[{"name":"Department of Medicine, European Institute of Oncology, Milan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia","family":"Lorizzo","sequence":"additional","affiliation":[{"name":"Department of Medicine, European Institute of Oncology, Milan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Farris","sequence":"additional","affiliation":[{"name":"Division of Oncology, AOU Sassari, Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Fazio","sequence":"additional","affiliation":[{"name":"Department of Medicine, Upper Gastro-Intestinal Tract and Neuroendocrine Tumors Unit, European Institute of Oncology, Milan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"bibr1-030089161209800224","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.05.013"},{"key":"bibr2-030089161209800224","unstructured":"Italian Cancer Figures \u2014 Report 2009. 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