{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:12:22Z","timestamp":1777918342052,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although patients with Hodgkin's lymphoma (HL) achieve prolonged survival, long-term complications are a major cause of morbidity and mortality among long-term survivors of HL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively evaluated long-term complications in 336 HL survivors treated between January 1990 and January 2006 at the Department of Medical Oncology of the Hacettepe University Institute of Oncology who were &gt;16 years old at presentation. All patients were regularly followed up every 3 months for the first 2 years after complete response, biannually for 3 years, and annually after 5 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median follow-up was 8.5 years. The mean age (\u00b1SD) of the patients at the time of diagnosis was 35.7 \u00b1 13.1 years. The male to female ratio was 61%\/39%. During follow-up, 29 second malignancies (8.6%) were diagnosed in 28 patients with HL; 22 were solid tumors and 7 were hematological malignancies. Forty-seven (14.0%) of all patients with HL were found to have thyroid abnormalities. During follow-up, 54 (16.1%) patients developed cardiovascular complications. Overall, 29 (8.6%) patients developed late pulmonary toxicities. The cumulative number of chronic viral infections was 13 (3.9%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Long-term survivors of HL need to be properly followed up not only for disease control but also for evaluation of possible late morbidities to minimize the consequences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089161209800510","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T04:32:02Z","timestamp":1519705922000},"page":"601-606","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Long-Term Complications in Hodgkin's Lymphoma Survivors"],"prefix":"10.1177","volume":"98","author":[{"given":"Saadettin","family":"Kilickap","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Barista","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukran","family":"Ulger","sequence":"additional","affiliation":[{"name":"Radiotherapy Center, Ataturk Chest Diseases and Chest Surgery Training and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Celik","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugur","family":"Selek","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Gullu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferah","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayse","family":"Kars","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yavuz","family":"Ozisik","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hacettepe University Institute of Oncology, Ankara, 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