{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T02:43:10Z","timestamp":1794278590017,"version":"4.9.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and background<\/jats:title>\n                    <jats:p>\n                      To evaluate the clinical outcome of a cohort of localized prostate cancer patients treated with\n                      <jats:sup>125<\/jats:sup>\n                      I permanent brachytherapy at the University of Turin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and study design<\/jats:title>\n                    <jats:p>\n                      A retrospective analysis was carried out on 167 consecutive patients with early stage prostate adenocarcinoma who underwent\n                      <jats:sup>125<\/jats:sup>\n                      I brachytherapy between January 2003 and December 2010. A minimum follow-up of \u226512 months was mandatory for inclusion. Biochemical disease-free survival (defined on the basis of the ASTRO definition and the ASTRO-Phoenix definition) was chosen as the primary end point. Secondary end points were gastrointestinal and genitourinary toxicity (acute and late, defined according to the RTOG scale).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>With a median follow-up of 42 months (range, 13.5\u201390.7), biochemical disease-free survival at 3 and 5 years was respectively 91.1% and 85.7%, according to the ASTRO definition and 94.5% and 85.1% according to ASTRO-Phoenix definition (for statistical purposes, only the ASTRO definition was used). Hormone treatment and nadir PSA (cutoff of 0.35 ng\/ml) were the only factors affecting biochemical disease-free survival both on univariate ( P = 0.02 and P = 0.001, respectively) and multivariate analysis (HR 0.024; P = 0.021 and HR 21.6; P = 0.006, respectively). Only 3.6% of patients experienced \u2265grade 3 acute urinary toxicity and 5% \u2265grade 3 late urinary toxicity. Prior transurethral prostate resection was the only independent predictor of grade 3 late urinary toxicity on multivariate analysis (HR 0.13; P = 0.009).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This mono-institutional series confirmed that brachytherapy is an effective and safe treatment modality for localized prostate cancer, with acceptable short- and long-term morbidity rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089161309900114","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T04:35:21Z","timestamp":1519706121000},"page":"83-87","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["<sup>125<\/sup>\n                    I Brachytherapy for Localized Prostate Cancer: A Single Institution Experience"],"prefix":"10.1177","volume":"99","author":[{"given":"Alessia","family":"Guarneri","sequence":"first","affiliation":[{"name":"Radiation Oncology, Department of Medical and Surgical Sciences, University of Turin, S Giovanni Battista, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Botticella","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Department of Medical and Surgical Sciences, University of Turin, S Giovanni Battista, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Riccardo","family":"Filippi","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Department of Medical and Surgical Sciences, University of Turin, S Giovanni Battista, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Munoz","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Department of Medical and Surgical Sciences, University of Turin, S Giovanni Battista, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Beltramo","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Department of Medical and Surgical Sciences, University of Turin, S Giovanni Battista, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Casetta","sequence":"additional","affiliation":[{"name":"Radiation Urology, Department of Medical and Surgical Sciences, University of Turin, S Giovanni Battista, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca Romana","family":"Giglioli","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Department of Medical and Surgical Sciences, University of Turin, S Giovanni Battista, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Tizzani","sequence":"additional","affiliation":[{"name":"Radiation Urology, Department of Medical and Surgical Sciences, University of Turin, S Giovanni Battista, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Ragona","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Department of Medical and Surgical Sciences, University of Turin, S Giovanni Battista, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Ricardi","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Department of Medical and Surgical Sciences, University of Turin, S Giovanni Battista, Turin, 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