{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:43:44Z","timestamp":1789771424931,"version":"4.0.1"},"reference-count":42,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and background<\/jats:title>\n                    <jats:p>For advanced cancers of the bile duct, gallbladder and ampulla of Vater, there are only a few treatment options. We explored the efficacy of the combination of gemcitabine, 5-fluorouracil and cisplatin for advanced biliary cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      From September 2003 to April 2010, 28 patients with recurrent or metastatic biliary tract cancer were enrolled. A treatment regimen consisting of gemcitabine (800 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      at a fixed dose rate on days 1 and 8), 5-fluorouracil (1 g\/m\n                      <jats:sup>2<\/jats:sup>\n                      \/day continuous infusion for 4 days) and cisplatin (60 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      on day 2) was repeated every 3 weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One (3.6%) patient showed complete response, 8 (28.6%) partial response, 14 (50%) stable disease and 5 (17.9%) disease progression. Overall, the objective response rate was 32.1% (95% CI, 17.9\u201350.6%) and the disease control rate was 82.1% (95% CI, 64.4\u201392.1%). Median progression-free survival and overall survival were 7.6 months (95% CI, 5.5\u20139.7) and 11.2 months (95% CI, 6.8\u201315.5), respectively. G3\/4 neutropenia was observed in 44 (24.3%) of 181 cycles and G3\/4 thrombocytopenia in 48 (26.5%) of 181 cycles. There was no treatment-related mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The combined regimen of gemcitabine, 5-fluorouracil and cisplatin has comparable activity for patients with advanced cancer of the bile duct, gallbladder and ampulla of Vater. Toxicity was tolerable but substantial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089161309900203","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T04:38:15Z","timestamp":1519706295000},"page":"139-144","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Phase II Trial of Combination Chemotherapy with Gemcitabine, 5-Fluorouracil and Cisplatin for Advanced Cancers of the Bile Duct, Gallbladder, and Ampulla of Vater"],"prefix":"10.1177","volume":"99","author":[{"given":"Byeong Seok","family":"Sohn","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Jin","family":"Yuh","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Joo","family":"Jeon","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Rok","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, 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