{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:12:48Z","timestamp":1777918368622,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To retrospectively evaluate the outcome of patients with inoperable non-small-cell lung cancer treated with primary external beam radiotherapy combined with high-dose-rate endobronchial brachytherapy boost.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>Between 1988 and 2005, 35 patients with non-small-cell lung cancer (stage I-III) ineligible for surgical resection and\/or chemotherapy, were primarily treated with external beam radiotherapy with a median total dose of 50 Gy (range, 46\u201360). A median of 3 fractions high-dose-rate endobronchial brachytherapy was applied as a boost after external beam radiotherapy, the median total dose was 15 Gy (range, 8\u201320). High-dose-rate endobronchial brachytherapy was carried out with iridium-192 sources (370 GBq) and prescribed to 1 cm distance from the source axis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>With a median follow-up of 26 months from the first fraction of high-dose-rate endobronchial brachytherapy, the 1-, 2- and 5-year overall (local progression-free) survival rates were 76% (76%), 61% (57%) and 28% (42%), respectively. Complete or partial remission rates 6 to 8 weeks after treatment were 57% and 17%, respectively. Significant prognostic favorable factors were a complete remission 6\u20138 weeks after treatment and a negative nodal status. In patients without mediastinal node involvement, a long-term local control could be achieved with 56% 5-year local progression-free survival. Common Toxicity Criteria grade 3 toxicities were hemoptysis (n = 2) and necrosis (n = 1). One fatal hemoptysis occurred in combination with a local tumor recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The combination of external beam radiotherapy with high-dose-rate endobronchial brachytherapy boost is an effective primary treatment with acceptable toxicity in patients with non-small-cell lung cancer ineligible for surgical resection and\/or chemotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089161309900211","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T04:38:15Z","timestamp":1519706295000},"page":"183-190","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Primary Radiotherapy with Endobronchial High-Dose-Rate Brachytherapy Boost for Inoperable Lung Cancer: Long-Term Results"],"prefix":"10.1177","volume":"99","author":[{"given":"Nathalie","family":"Rochet","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Thoraxklinik, University of Heidelberg, Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Hauswald","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Thoraxklinik, University of Heidelberg, Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva Maria","family":"Stoiber","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Thoraxklinik, University of Heidelberg, Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank W","family":"Hensley","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Thoraxklinik, University of Heidelberg, Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinrich D","family":"Becker","sequence":"additional","affiliation":[{"name":"Interdisciplinary Section of Endoscopy, Thoraxklinik, University of Heidelberg, Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juergen","family":"Debus","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Thoraxklinik, University of Heidelberg, Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Lindel","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Thoraxklinik, University of Heidelberg, Heidelberg, 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