{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:12:51Z","timestamp":1777918371217,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec>\n                    <jats:title>Aims and background<\/jats:title>\n                    <jats:p>Adult sarcomas of the head and neck region (HNSs) are considered a rare clinicopathological entity. They account for only 2\u201315% of all adult sarcomas and for less than 1% of all head and neck malignancies. The preferred initial treatment option is wide surgical excision. Whenever surgery is considered infeasible, a frontline combined-modality approach including radiotherapy and chemotherapy might be proposed. We here report on a case of localized sarcoma of the maxillary sinus treated with induction chemotherapy and subsequent intensity-modulated radiation therapy (IMRT), achieving a persistent complete remission status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A 66-year-old man was referred to our institution hospital for left-sided facial pain with swollen left cheek and ipsilateral facial palsy. Magnetic resonance imaging showed a mass within the left maxillary sinus extending to the orbital floor and adjacent alveolar bones. Histological examination of the biopsy specimen demonstrated a myxofibrosarcoma. The patient underwent induction chemotherapy with gemcitabine 900 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (days 1\u20138) and taxotere 80 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      every 3 weeks for 3 cycles and sequential simultaneous integrated boost (SIB) IMRT up to a total dose of 70 Gy\/35 fractions to the macroscopic disease with 59.5 Gy\/35 fractions to the level IB-II lymph nodes in the left neck.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Treatment was well tolerated with mild acute toxicity. Complete remission was achieved at restaging MRI 6 months after the end of the combined modality approach. The patient remains in complete, unmaintained clinical and instrumental complete remission 18 months after treatment, with no late side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Combination therapy with induction chemotherapy and sequential SIB-IMRT could therefore be a promising modality for head and neck sarcomas, allowing for simultaneous tumor control and normal tissue sparing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/030089161309900235","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T04:38:15Z","timestamp":1519706295000},"page":"e80-e83","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Combined chemoradiation for head and neck region myxofibrosarcoma of the maxillary sinus"],"prefix":"10.1177","volume":"99","author":[{"given":"Domenico","family":"Cante","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, ASL TO4, Ospedale Civile di Ivrea, Ivrea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierfrancesco","family":"Franco","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, Tomotherapy Unit, Ospedale Regionale U Parini, AUSL Valle d'Aosta, Aosta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piera","family":"Sciacero","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, ASL TO4, Ospedale Civile di Ivrea, Ivrea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe Franco","family":"Girelli","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, ASL TO4, Ospedale Civile di Ivrea, Ivrea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria Casanova","family":"Borca","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, ASL TO4, Ospedale Civile di Ivrea, Ivrea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Pasquino","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, ASL TO4, Ospedale Civile di Ivrea, Ivrea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santi","family":"Tofani","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, ASL TO4, Ospedale Civile di Ivrea, Ivrea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastiano","family":"Bombaci","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, ASL TO4, Ospedale Civile di Ivrea, Ivrea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Migliaccio","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, Tomotherapy Unit, Ospedale Regionale U Parini, AUSL Valle d'Aosta, Aosta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamaria","family":"Marra","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, ASL TO4, Ospedale Civile di Ivrea, Ivrea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianmauro","family":"Numico","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Ospedale Regionale U Parini, AUSL Valle d'Aosta, Aosta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rosa","family":"La Porta","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, ASL TO4, Ospedale Civile di Ivrea, Ivrea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Ricardi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Radiation Oncology Unit, University of Turin, Ospedale San Giovanni Battista, Turin, 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