{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:13:38Z","timestamp":1777918418000,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>\n                    We describe a case of lung adenocarcinoma with multiple postoperative bone metastases that showed a gradual but complete response to combined administration of erlotinib and zoledronic acid. A 76-year-old man with moderately differentiated adenocarcinoma underwent a radical left upper lobectomy and mediastinal lymph node dissection. Three and a half years after the operation, serum carcinoembryonic antigen (CEA) was elevated and\n                    <jats:sup>18<\/jats:sup>\n                    F-fluorodeoxyglucose positron emission tomography (\n                    <jats:sup>18<\/jats:sup>\n                    FDG-PET) revealed multiple bone metastases. Pretreatment evaluation of EGFR mutations in the resected primary adenocarcinoma specimen showed an L858R mutation in exon 21. Gefitinib was started as first-line treatment. However, evaluation 1 month after administration revealed progressive disease. Erlotinib was started as second-line treatment, and evaluation 1 month after administration revealed that the disease was stable. Administration of zoledronic acid was then begun with continuation of erlotinib. After 2 courses of zoledronic acid, the serum CEA level had not changed but the maximum standardized uptake values of each region uniformly decreased. Furthermore, the uptake of\n                    <jats:sup>18<\/jats:sup>\n                    FDG completely disappeared after 6 courses. Subsequently, the serum CEA level continued to decrease and the disappearance of\n                    <jats:sup>18<\/jats:sup>\n                    FDG uptake was confirmed after 10 courses (12 months after initiation of erlotinib administration). Our results suggest that the combined administration of both drugs is effective against bone metastases.\n                  <\/jats:p>","DOI":"10.1177\/030089161410000223","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T04:42:59Z","timestamp":1519706579000},"page":"e45-e48","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A Case of Lung Adenocarcinoma with Postoperative Recurrence of Multiple Bone Metastases that Showed a Gradual Complete Response to Combined Administration of Erlotinib and Zoledronic Acid"],"prefix":"10.1177","volume":"100","author":[{"given":"Takayuki","family":"Kosaka","sequence":"first","affiliation":[{"name":"Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ei","family":"Yamaki","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Mogi","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kuwano","sequence":"additional","affiliation":[{"name":"Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, 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