{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:13:47Z","timestamp":1777918427702,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Malignant pleural mesothelioma (MPM) diagnosis is known to be difficult. We report on the diagnostic elements available in life in an MPM necropsy case series and describe the frequency of non-neoplastic asbestos-related diseases as biological exposure indices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We reviewed pathologic and clinical records of an unselected series of autopsies (1977\u20132016) in patients with MPM employed in the Monfalcone shipyards or living with shipyard workers. We assessed the consistency with autopsy results of diagnoses based on, respectively, radiologic, cytologic, and histologic findings, with and without immunophenotyping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Data on 171 cases were available: for 169, autopsy confirmed the MPM diagnosis. In life, 119 cases had histologic confirmation of diagnosis, whereas 7 were negative; all cases without immunophenotypization were autoptic MPMs. Cytology alone had been positive in 18 autoptic MPM cases, negative in 14. Radiologic imaging alone had been positive in another 16, negative in 11. In the 2 cases not confirmed at autopsy, MPM had been suspected by chest computed tomography only. Bilateral pleural plaques were found in 144 and histologic evidence of asbestosis in 62 cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Autopsies confirmed 169\/171 cases, including cases that would not be considered as certain based on diagnosis in life. Radiologic imaging, cytologic examination of pleural effusions, or both combined had low sensitivity but high positive predictive value: when they are positive, proceeding to thoracoscopy should be justified. MPM has been correctly diagnosed even without immunohistochemistry. The prevalence of pleural plaques and asbestosis was high due to severity of asbestos exposures in these cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300891618765538","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T06:02:51Z","timestamp":1522994571000},"page":"304-311","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["On the diagnosis of malignant pleural mesothelioma: A necropsy-based study of 171 cases (1997\u20132016)"],"prefix":"10.1177","volume":"105","author":[{"given":"Pietro Gino","family":"Barbieri","sequence":"first","affiliation":[{"name":"Retired from Mesothelioma Registry, Occupational Health Unit, Local Health Authority of Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Mirabelli","sequence":"additional","affiliation":[{"name":"Unit of Cancer Epidemiology, CPO-Piemonte and Department of Medical Sciences, Universit\u00e0 di Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Magnani","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Unit, Department of Translational Medicine, University of Eastern Piedmont and CPO-Piemonte, Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Brollo","sequence":"additional","affiliation":[{"name":"Laboratory of Pathological Anatomy of Monfalcone, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,4,6]]},"reference":[{"key":"bibr1-0300891618765538","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.3462"},{"key":"bibr2-0300891618765538","doi-asserted-by":"publisher","DOI":"10.1136\/oem.55.11.760"},{"key":"bibr3-0300891618765538","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601638"},{"key":"bibr4-0300891618765538","first-page":"316","volume":"23","author":"Merler E","year":"1999","journal-title":"Epidemiol Prev"},{"key":"bibr5-0300891618765538","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20820"},{"key":"bibr6-0300891618765538","doi-asserted-by":"publisher","DOI":"10.1053\/sonc.2002.30230"},{"key":"bibr7-0300891618765538","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2012.11.004"},{"key":"bibr8-0300891618765538","doi-asserted-by":"publisher","DOI":"10.1177\/030089161209800206"},{"key":"bibr9-0300891618765538","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00063109"},{"key":"bibr10-0300891618765538","unstructured":"Quaderni del Ministero della Salute N. 15. Stato dell\u2019arte e prospettive in materia di contrasto alle patologie asbesto-correlate. Maggio-Giugno 2012. Available at: http:\/\/www.quadernidellasalute.it\/portale\/quaderni\/dettaglioQuaderni.jsp?lingua=italiano&id=2570 (accessed 30 October 2017)."},{"key":"bibr11-0300891618765538","first-page":"254","volume":"5","author":"Zandwijk N","year":"2013","journal-title":"J Thorac Dis"},{"key":"bibr12-0300891618765538","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2016.05.004"},{"key":"bibr13-0300891618765538","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2010-0604-RA"},{"key":"bibr14-0300891618765538","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012-0214-OA"},{"key":"bibr15-0300891618765538","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2013-0381-RA"},{"key":"bibr16-0300891618765538","unstructured":"Nesti M, Adamoli S, Ammirabile F, et al. Linee guida per la rilevazione e la definizione dei casi di mesotelioma maligno e la trasmissione delle informazioni all\u2019ISPESL da parte dei Centri Operativi Regionali. Rome: Istituto Superiore per la Prevenzione e la Sicurezza del Lavoro (ISPESL); 2004."},{"key":"bibr17-0300891618765538","doi-asserted-by":"publisher","DOI":"10.5858\/134.3.462"},{"key":"bibr18-0300891618765538","unstructured":"Segal A, Whitaker D, Henderson D, Shilkin K. Pathology of mesothelioma. In: Robinson WS, Chahinian AP, eds. Mesothelioma. London: Martin Dunitz; 2002."},{"key":"bibr19-0300891618765538","first-page":"1","volume":"30","author":"Smith TJ","year":"2014","journal-title":"Turk Patoloji Derg"},{"key":"bibr20-0300891618765538","doi-asserted-by":"publisher","DOI":"10.4103\/0971-3026.125577"},{"key":"bibr21-0300891618765538","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-206054"},{"key":"bibr22-0300891618765538","doi-asserted-by":"publisher","DOI":"10.1148\/rg.241035058"},{"key":"bibr23-0300891618765538","doi-asserted-by":"publisher","DOI":"10.1016\/S0720-048X(01)00426-0"},{"key":"bibr24-0300891618765538","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0022-5223(19)35312-7","volume":"96","author":"Rusch VW","year":"1988","journal-title":"J Thorac Cardiovasc Surg"},{"key":"bibr25-0300891618765538","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(98)00083-X"},{"key":"bibr26-0300891618765538","doi-asserted-by":"publisher","DOI":"10.5858\/133.8.1317"},{"key":"bibr27-0300891618765538","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2010.00840.x"},{"key":"bibr28-0300891618765538","doi-asserted-by":"crossref","first-page":"26","DOI":"10.4103\/1742-6413.170726","volume":"12","author":"Hjerpe A","year":"2015","journal-title":"CytoJournal"},{"key":"bibr29-0300891618765538","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.20"},{"key":"bibr30-0300891618765538","unstructured":"Hornby AS. Oxford Advanced Learner\u2019s Dictionary, Sixth Edition. Oxford: Oxford University Press; 2000."},{"key":"bibr31-0300891618765538","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23874"},{"key":"bibr32-0300891618765538","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0274(199711)32:5<445::AID-AJIM3>3.0.CO;2-R"},{"key":"bibr33-0300891618765538","first-page":"55","volume":"104","author":"De Zotti R","year":"2013","journal-title":"Med Lav"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300891618765538","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300891618765538","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300891618765538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:38:41Z","timestamp":1777660721000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300891618765538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,6]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1177\/0300891618765538"],"URL":"https:\/\/doi.org\/10.1177\/0300891618765538","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,6]]}}}