{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:16:50Z","timestamp":1778537810785,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T00:00:00Z","timestamp":1523404800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>This retrospective study analyzes the safety and feasibility of concurrent chemoradiotherapy (CRT) in adjuvant treatment of soft tissue sarcoma (STS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 158 patients with STS were retrospectively analyzed. Anthracycline-based computed tomography was performed in high-risk patients. Acute radiotherapy toxicity and chemotherapy-related toxicity were assessed according to the Common Terminology Criteria for Adverse Events 4.0; late radiotherapy toxicity was recorded according to Radiation Therapy Oncology Group\/European Organization for Research and Treatment of Cancer criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Fifty-four (34.2%) patients received CRT. Mean follow up was 5.4 years (range .2\u201321.1 years). Local DFS\u2013recurrence-free survival, distant DFS\u2013relapse-free survival, and overall survival were 79.1%, 76.4%, and 64.6%, respectively, at last follow-up. Leukopenia occurred in 11.4% of patients. Skin acute toxicity developed in 60.1% of patients and determined interruption of radiotherapy treatment in 19 (12%) patients. Nineteen patients (12%) experienced moderate fibrosis (grade 2). Mild and moderate joint stiffness was recorded in 16 (10.1%) patients. Size \u22655 cm was the only predictor of local recurrence at multivariate analysis (hazard ratio [HR] 9.65, 95% confidence interval [CI] 1.28\u201372.83, p = .028). Age and stage resulted as independent distant relapse predictors (HR 4.77, 95% CI 1.81\u201312.58, p = .002 and HR 4.83, CI 1.41\u201316.57, p = .012, respectively). At Cox regression univariate analysis, Karnofsky Performance Status, size, and stage were significant survival predictors (HR 2.23, 95% CI 1.02\u20134.87, p = .045; HR 2.88, 95% CI 1.10\u20137.52, p = .031; HR 2.59, 95% CI 1.11\u20136.04, p = .028).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Concurrent CRT is a well-tolerated treatment option with no additional toxicity compared to exclusive radiotherapy or sequential CRT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300891618765565","type":"journal-article","created":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T07:37:40Z","timestamp":1523432260000},"page":"322-329","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Safety of concurrent adjuvant radiotherapy and chemotherapy for locally advanced soft tissue sarcoma"],"prefix":"10.1177","volume":"104","author":[{"given":"Daniela","family":"Greto","sequence":"first","affiliation":[{"name":"Department of Radiation-Oncology, Azienda Ospedaliero Universitaria Careggi, University of Florence, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Loi","sequence":"additional","affiliation":[{"name":"Department of Radiation-Oncology, Azienda Ospedaliero Universitaria Careggi, University of Florence, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calogero","family":"Saieva","sequence":"additional","affiliation":[{"name":"Molecular and Nutritional Epidemiology Unit, ISPO (Cancer Research and Prevention Institute), Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Muntoni","sequence":"additional","affiliation":[{"name":"Department of Radiation-Oncology, Azienda Ospedaliero Universitaria Careggi, University of Florence, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Delli Paoli","sequence":"additional","affiliation":[{"name":"Department of Radiation-Oncology, Azienda Ospedaliero Universitaria Careggi, University of Florence, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlotta","family":"Becherini","sequence":"additional","affiliation":[{"name":"Department of Radiation-Oncology, Azienda Ospedaliero Universitaria Careggi, University of Florence, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Ciabatti","sequence":"additional","affiliation":[{"name":"Department of Radiation-Oncology, Azienda Ospedaliero Universitaria Careggi, University of Florence, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Perna","sequence":"additional","affiliation":[{"name":"Department of Radiation-Oncology, Azienda Ospedaliero Universitaria Careggi, University of Florence, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Campanacci","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Oncology and Reconstructive Surgery, Azienda Ospedaliero Universitaria Careggi, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Terziani","sequence":"additional","affiliation":[{"name":"Department of Radiation-Oncology, Azienda Ospedaliero Universitaria Careggi, University of Florence, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Beltrami","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Oncology and Reconstructive Surgery, Azienda Ospedaliero Universitaria Careggi, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Scoccianti","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Oncology and Reconstructive Surgery, Azienda Ospedaliero Universitaria Careggi, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierluigi","family":"Bonomo","sequence":"additional","affiliation":[{"name":"Department of Radiation-Oncology, Azienda Ospedaliero Universitaria Careggi, University of Florence, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Icro","family":"Meattini","sequence":"additional","affiliation":[{"name":"Department of Radiation-Oncology, Azienda Ospedaliero Universitaria Careggi, University of Florence, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isacco","family":"Desideri","sequence":"additional","affiliation":[{"name":"Department of Radiation-Oncology, Azienda Ospedaliero Universitaria 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