{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:14:02Z","timestamp":1777918442677,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>In patients with cutaneous graft versus host disease (GvHD) that is resistant to traditional steroid therapy, imatinib is a first-generation tyrosine kinase inhibitor that seems to be a viable option. However, its antifibrotic activity can be associated with serosal inflammation and fluid retention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We report a case of an adult patient who, after allogenic hematopoietic stem cell transplantation, developed a GvHD treated with imatinib at low dosage, followed by multiorgan failure. Clinical examination and cardiac ultrasound were unable to clearly recognize the low cardiac output state; laboratory analysis, filling pressure, and computed tomography examination clarified the correct diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Low cardiac output state, secondary to pericardial effusion, is a diagnostic challenge. However, the association of four elements can help in its early recognition: increase in lactate levels and central venous pressure, associated with a low central venous saturation and a low brain natriuretic peptide level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Pericardial effusion with cardiac tamponade is a difficult diagnosis even with ultrasound. Lactate levels, central venous pressure plus venous saturation, and brain natriuretic peptide could help in early detection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300891618794890","type":"journal-article","created":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T07:57:12Z","timestamp":1545983832000},"page":"NP14-NP16","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Cardiac tamponade and graft versus host disease: one more reason to remember"],"prefix":"10.1177","volume":"104","author":[{"given":"Luigi","family":"Vetrugno","sequence":"first","affiliation":[{"name":"Anesthesiology and Intensive Care Clinic, Department of Medicine, University of Udine, Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serana","family":"Tomasino","sequence":"additional","affiliation":[{"name":"Anesthesiology and Intensive Care Clinic, Department of Medicine, University of Udine, Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Battezzi","sequence":"additional","affiliation":[{"name":"Anesthesiology and Intensive Care Clinic, Department of Medicine, University of Udine, Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Parisella","sequence":"additional","affiliation":[{"name":"Anesthesiology and Intensive Care Clinic, Department of Medicine, University of Udine, Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Bernardinetti","sequence":"additional","affiliation":[{"name":"Unit of Anesthesia, Intensive Care and Pain Management, University Hospital School of Medicine, Campus BioMedico of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Bove","sequence":"additional","affiliation":[{"name":"Anesthesiology and Intensive Care Clinic, Department of Medicine, University of Udine, Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,12,28]]},"reference":[{"key":"bibr1-0300891618794890","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.03.006"},{"key":"bibr2-0300891618794890","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10186"},{"key":"bibr3-0300891618794890","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-009-0110-4"},{"key":"bibr4-0300891618794890","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2004.00347.x"},{"key":"bibr5-0300891618794890","first-page":"45","volume":"13","author":"Kavitha K","year":"2017","journal-title":"Clin Proc"},{"key":"bibr6-0300891618794890","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-018-5191-z"},{"key":"bibr7-0300891618794890","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1935.02760090018005"},{"key":"bibr8-0300891618794890","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200108000-00006"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300891618794890","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300891618794890","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300891618794890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:39:08Z","timestamp":1777660748000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300891618794890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1177\/0300891618794890"],"URL":"https:\/\/doi.org\/10.1177\/0300891618794890","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12]]}}}