{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:14:26Z","timestamp":1777918466465,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the frequency of neoadjuvant therapy (NT) in women with stage I\u2013III breast cancer in Italy and whether it is influenced by biological characteristics, screening history, and geographic area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data from the High Resolution Study conducted in 7 Italian cancer registries were used; they are a representative sample of incident cancers in the study period (2009\u20132013). Included were 3546 women aged &lt;85 years (groups &lt;50, 50\u201369, 70\u201364, and 75+) with stage I\u2013III breast cancer at diagnosis who underwent surgery. Women were classified as receiving NT if they received chemotherapy, target therapy, and\/or hormone therapy before the first surgical treatment. Logistic models were built to test the association with biological and contextual variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Only 8.2% of women (290 cases) underwent NT; the treatment decreases with increasing age (14.5% in age &lt;50 and 2.2% in age 75+), is more frequent in women with negative receptors (14.8%), HER2-positive (15.7%), and triple-negative (15.6%). The multivariable analysis showed the probability of receiving NT is higher in stage III (odds ratio [OR] 3.83; 95% confidence interval [CI] 2.83\u20135.18), luminal B (OR 1.87; 95% CI 1.27\u20132.76), triple-negatives (OR 1.88; 95% CI 1.15\u20133.08), and in symptomatic cancers (OR 1.98; 95% CI 1.13\u20133.48). Use of NT varied among geographic areas: Reggio Emilia had the highest rates (OR 2.29; 95% CI 1.37\u20133.82) while Palermo had the lowest (OR 0.41; 95% CI 0.24\u20130.68).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The use of NT in Italy is limited and variable. There are no signs of greater use in hospitals with more advanced care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300891619869505","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T06:15:48Z","timestamp":1568009748000},"page":"488-493","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Neoadjuvant therapy for breast cancer"],"prefix":"10.1177","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4850-2678","authenticated-orcid":false,"given":"Lucia","family":"Mangone","sequence":"first","affiliation":[{"name":"Epidemiology Unit, Azienda Unit\u00e0 Sanitaria Locale-IRCCS Reggio Emilia, Reggio Emilia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Mancuso","sequence":"additional","affiliation":[{"name":"Epidemiology Unit, Azienda Unit\u00e0 Sanitaria Locale-IRCCS Reggio Emilia, Reggio Emilia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Tagliabue","sequence":"additional","affiliation":[{"name":"Analytical Epidemiology and Health Impact Unit, Research Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa Angela","family":"Filiberti","sequence":"additional","affiliation":[{"name":"RTR Liguria, IRCCS AOU SM-IST, Liguria, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliano","family":"Carrozzi","sequence":"additional","affiliation":[{"name":"Department of Public Health, Local Health Unit, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Iacovacci","sequence":"additional","affiliation":[{"name":"Latina Cancer Registry, Lazio, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Mazzucco","sequence":"additional","affiliation":[{"name":"Department of Health Promotion and of Maternal and Childhood Sciences, University of Palermo, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Tumino","sequence":"additional","affiliation":[{"name":"Histopathology Department and Cancer Registry, Provincial Health Authority, ASP Ragusa, Ragusa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Minicozzi","sequence":"additional","affiliation":[{"name":"Analytical Epidemiology and Health Impact Unit, Research Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Sant","sequence":"additional","affiliation":[{"name":"Analytical Epidemiology and Health Impact Unit, Research Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Giorgi Rossi","sequence":"additional","affiliation":[{"name":"Epidemiology Unit, Azienda Unit\u00e0 Sanitaria Locale-IRCCS Reggio Emilia, Reggio Emilia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,9,9]]},"reference":[{"key":"bibr1-0300891619869505","volume-title":"I Numeri del Cancro in Italia 2017: Il Pensiero Scientifico Editore","author":"AIOM AIRTUM","year":"2017"},{"key":"bibr2-0300891619869505","unstructured":"TNM Classification of Malignant Tumors\n                      , 7th edition. Hoboken, NJ: Blackwell Publishing; 2010."},{"key":"bibr3-0300891619869505","first-page":"1","volume":"41","author":"Coviello V","year":"2017","journal-title":"Epidemiol Prev"},{"key":"bibr4-0300891619869505","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.19130"},{"key":"bibr5-0300891619869505","doi-asserted-by":"publisher","DOI":"10.1258\/jms.2012.012078"},{"key":"bibr6-0300891619869505","doi-asserted-by":"publisher","DOI":"10.1177\/0300891618766177"},{"key":"bibr7-0300891619869505","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62422-8"},{"key":"bibr8-0300891619869505","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv298"},{"key":"bibr9-0300891619869505","volume-title":"Clinical Practice Guidelines in Oncology, Breast Cancer, Version 1","author":"NCCN","year":"2018"},{"key":"bibr10-0300891619869505","volume-title":"Linee Guida Neoplasie della Mammella, Edizione 2017","author":"Associazione Italiana di Oncologia Medica","year":"2017"},{"key":"bibr11-0300891619869505","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm481"},{"key":"bibr12-0300891619869505","volume-title":"The Requirements of a Specialist Breast Unit: EUSOMA","author":"EUSOMA Secretariat","year":"2000"},{"key":"bibr13-0300891619869505","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2016.08.541"},{"key":"bibr14-0300891619869505","unstructured":"European High Resolution Studies, http:\/\/www.hrstudies.eu (accessed 15 October, 2018)."},{"key":"bibr15-0300891619869505","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.7.2483"},{"key":"bibr16-0300891619869505","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.22.4224"},{"key":"bibr17-0300891619869505","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2018.03.018"},{"key":"bibr18-0300891619869505","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29348"},{"key":"bibr19-0300891619869505","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-018-4727-9"},{"key":"bibr20-0300891619869505","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020208719902"},{"key":"bibr21-0300891619869505","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2017.7063"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300891619869505","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300891619869505","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300891619869505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:39:47Z","timestamp":1777660787000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300891619869505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,9]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1177\/0300891619869505"],"URL":"https:\/\/doi.org\/10.1177\/0300891619869505","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,9]]}}}