{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:15:41Z","timestamp":1777918541907,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T00:00:00Z","timestamp":1619308800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"crossref","award":["Ricerca Corrente and 5x1000 funds"],"award-info":[{"award-number":["Ricerca Corrente and 5x1000 funds"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG-13218"],"award-info":[{"award-number":["IG-13218"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG-14300"],"award-info":[{"award-number":["IG-14300"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To compare different stereotactic body techniques\u2014intensity-modulated radiotherapy with photons and protons, applied to radiotherapy of prostatic cancer\u2014with simultaneous integrated boost (SIB) on the dominant intraprostatic lesion (DIL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Ten patients were selected for this planning study. Dosimetric results were compared between volumetric modulated arc therapy, intensity-modulated radiation therapy (IMRT), and intensity-modulated proton therapy both with two (IMPT 2F) and five fields (IMPT 5F) planning while applying the prescription schemes of 7.25 Gy\/fraction to the prostate gland and 7.5 Gy\/fraction to the DIL in 5 fractions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Comparison of the coverages of the planning target volumes showed that small differences exist. The IMPT-2F-5F techniques allowed higher doses in the targets; conformal indexes resulted similar; homogeneity was better in the photon techniques (2%\u20135%). Regarding the organs at risk, all the techniques were able to maintain the dose well below the prescribed constraints: in the rectum, the IMPT-2F-5F and IMRT were more efficient in lowering the intermediate doses; in the bladder, the median dose was significantly better in the case of IMPT (2F\u20135F). In the urethra, the best sparing was achieved only by IMPT-5F.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Stereotactic radiotherapy with SIB for localized prostate cancer is feasible with all the investigated techniques. Concerning IMPT, the two-beam technique does not seem to have a greater advantage compared to the standard techniques; the 5-beam technique seems more promising also accounting for the range uncertainty.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03008916211011667","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T11:32:23Z","timestamp":1619350343000},"page":"263-269","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Ultrahypofractionated radiotherapy for localized prostate cancer with simultaneous boost to the dominant intraprostatic lesion: a plan comparison"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9894-068X","authenticated-orcid":false,"given":"Raffaella","family":"Cambria","sequence":"first","affiliation":[{"name":"Medical Physics Unit, Istituto Europeo di Oncologia IRCCS, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delia","family":"Ciardo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Bazani","sequence":"additional","affiliation":[{"name":"Medical Physics Unit, Istituto Europeo di Oncologia IRCCS, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floriana","family":"Pansini","sequence":"additional","affiliation":[{"name":"Medical Physics Unit, Istituto Europeo di Oncologia IRCCS, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Rondi","sequence":"additional","affiliation":[{"name":"Medical Physics Unit, Istituto Europeo di Oncologia IRCCS, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Maestri","sequence":"additional","affiliation":[{"name":"Medical Physics Unit, Istituto Europeo di Oncologia IRCCS, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9990-694X","authenticated-orcid":false,"given":"Dario","family":"Zerini","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Marvaso","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy"},{"name":"Department of Oncology and Hemato-oncology, Universit\u00e0 degli Studi di Milano, via Festa del Perdono, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pola","family":"Romanelli","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Timon","sequence":"additional","affiliation":[{"name":"Radiotherapy Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiana","family":"Fodor","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Istituto Europeo di Oncologia IRCCS, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Petralia","sequence":"additional","affiliation":[{"name":"Precision Imaging and Research Unit, Department of Medical Imaging and Radiation Sciences, Istituto Europeo di Oncologia IRCCS, via Ripamonti 435, Milan, Italy"},{"name":"Department of Oncology and Hemato-oncology, Universit\u00e0 degli Studi di Milano, via Festa del Perdono, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Alessi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Istituto Europeo di Oncologia IRCCS, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Pricolo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Istituto Europeo di Oncologia IRCCS, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Vischioni","sequence":"additional","affiliation":[{"name":"Centro Nazionale di Adroterapia Oncologica, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Fossati","sequence":"additional","affiliation":[{"name":"Centro Nazionale di Adroterapia Oncologica, Pavia, Italy"},{"name":"Department of Oncology and Hemato-oncology, Universit\u00e0 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