{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:44:34Z","timestamp":1783039474804,"version":"3.54.6"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>In developed countries, cancer remains the leading cause of pediatric death from illness after the neonatal period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To describe the end-of-life care characteristics of children and adolescents with solid tumors (ST) or hematologic malignancies (HM) who died from tumor progression in the \u00cele-de-France area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This is a regional, multicentric, retrospective review of medical files of all children and adolescents with cancer who died over a 1-year period. Extensive data from the last 3 months of life were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 99 eligible patients died at a median age of 9.8 years (range, 0.3\u201324 years). The most frequent terminal symptoms were pain (n = 86), fatigue (n = 84), dyspnea (n = 49), and anorexia (n = 41). Median number of medications per patient was 8 (range, 3\u201318). Patients required administration of opioids (n = 91), oxygen (n = 36), and\/or sedation (n = 61). Decision for palliative care was present in all medical records and do-not-resuscitate orders in 90\/99 cases. Symptom prevalence was comparable between children and adolescents with ST and HM. A wish regarding the place of death had been expressed for 64 patients and could be respected in 42 cases. Death occurred in hospital for 75 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study represents a large and informative cohort illustrating current pediatric palliative care approaches in pediatric oncology. End-of-life remains an active period of care requiring coordination of multiple care teams.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03008916211013384","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T03:24:48Z","timestamp":1620098688000},"page":"223-229","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["End-of-life care in children and adolescents with cancer: perspectives from a French pediatric oncology care network"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2710-8041","authenticated-orcid":false,"given":"Sophie","family":"Blais","sequence":"first","affiliation":[{"name":"Pediatric Department, Poissy Hospital, Poissy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Cohen-Gogo","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Gouache","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology, Trousseau Hospital (AP-HP), Sorbonne University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Guerrini-Rousseau","sequence":"additional","affiliation":[{"name":"Gustave Roussy Cancer Center, Department of Pediatric and Adolescent Oncology, Paris-Saclay University, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Brethon","sequence":"additional","affiliation":[{"name":"Pediatric Hematology Department, Robert Debr\u00e9 Hospital (AP-HP), Paris, France"},{"name":"RIFHOP, \u00cele-de-France Regional Network of Pediatric Hematology-Oncology, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilhem","family":"Rahal","sequence":"additional","affiliation":[{"name":"Adolescents and Young Adults Hematology Department, Saint-Louis Hospital (AP-HP), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Petit","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology, Trousseau Hospital (AP-HP), Sorbonne University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziella","family":"Raimondo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, H\u00f4pital d\u2019Enfants Margency, Margency, France"},{"name":"PALIPED, Regional Pediatric Palliative Care Resource Team of \u00cele-de-France, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Pediatric Department, Poissy Hospital, Poissy, France"},{"name":"RIFHOP, \u00cele-de-France Regional Network of Pediatric Hematology-Oncology, Paris, France"},{"name":"PALIPED, Regional Pediatric Palliative Care Resource Team of \u00cele-de-France, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Orbach","sequence":"additional","affiliation":[{"name":"RIFHOP, \u00cele-de-France Regional Network of Pediatric Hematology-Oncology, Paris, France"},{"name":"SIREDO Oncology Center (Care, Innovation and Research for Children and AYA with Cancer), PSL Research University, Institut Curie, Paris, 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