{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:48:27Z","timestamp":1781106507465,"version":"3.54.1"},"reference-count":11,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Anthracyclines are dispensable components of chemotherapy of patients with acute lymphoblastic leukemia (ALL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To analyze the efficacy and safety of induction with idarubicin (IDA) or liposoma daunorubicin (L-DNR) in treatment of adults with high-risk ALL (HR-ALL) (presence of mixed lineage leukemia gene [ MLL] rearrangements, t[1;19], or prednisone poor response).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Among 58 enrolled patients, 29 cases were defined as the IDA group and the other 29 patients were put into the L-DNR group. Both overall survival (OS) and progression-free survival (PFS) were estimated and overall response rate (ORR) was compared between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The L-DNR group\u2019s OS and PFS were insignificantly higher than in the IDA group ( P=0.261 and P=0.247). Although not significantly different, the ORR of adults with HR-ALL receiving L-DNR regimens was also higher than in the IDA group ( P=0.085). Comprehensive cytogenetic analysis revealed that patients harboring MLL rearrangement, E2A-PBX1, and P53 mutation had poorer prognosis than others. All 58 patients experienced hematologic response in this study; however, the length of hematologic response in the IDA group was significantly longer than in the L-DNR group ( P=0.005). The incidence of bleeding and infection was without significant difference between the groups (both P&gt;0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>L-DNR proved to be an effective drug within a multiagent approach, which shows a favorable overall profile, as well as similar adverse events when compared with IDA in HR-ALL. Patients with E2A-PBX1 are much more sensitive to L-DNR than IDA. Despite some progress made, outcomes in MLL rearrangement or P53 mutation carriers remain unsatisfactory, and intensive treatment will be critical.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03008916211032724","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T08:26:16Z","timestamp":1627028776000},"page":"182-188","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and safety of induction chemotherapy with daunorubicin or idarubicin in the treatment of an adult with acute lymphoblastic leukemia"],"prefix":"10.1177","volume":"108","author":[{"given":"Qi","family":"Zhang","sequence":"first","affiliation":[{"name":"Publicity Section, The Second Affiliated Hospital of Mudanjiang University, Mudanjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology Surgery, The Second Affiliated Hospital of Mudanjiang University, Mudanjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of ENT surgery, The Second Affiliated Hospital of Mudanjiang University, Mudanjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7461-8661","authenticated-orcid":false,"given":"Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology and Rheumatology, The Second Affiliated Hospital of Mudanjiang University, Mudanjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,7,23]]},"reference":[{"key":"bibr1-03008916211032724","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.02.053"},{"key":"bibr2-03008916211032724","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.04.002"},{"key":"bibr3-03008916211032724","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26156"},{"key":"bibr4-03008916211032724","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq213"},{"key":"bibr5-03008916211032724","first-page":"CD010432","volume":"6","author":"Li X","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr6-03008916211032724","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-019-03825-2"},{"key":"bibr7-03008916211032724","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8081175"},{"key":"bibr8-03008916211032724","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-484097"},{"key":"bibr9-03008916211032724","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-018-3338-1"},{"key":"bibr10-03008916211032724","doi-asserted-by":"publisher","DOI":"10.1007\/s11899-020-00582-5"},{"key":"bibr11-03008916211032724","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/bjh.13160","volume":"168","author":"Hastings C","year":"2015","journal-title":"Br J Haematol"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03008916211032724","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03008916211032724","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03008916211032724","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:41:53Z","timestamp":1777660913000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03008916211032724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,23]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1177\/03008916211032724"],"URL":"https:\/\/doi.org\/10.1177\/03008916211032724","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,23]]}}}