{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T06:52:32Z","timestamp":1779173552472,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001661","name":"universit\u00e4t heidelberg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Vaginal cancer is a rare disease for which prospective randomized trials do not exist. We aimed to assess survival outcomes, patterns of recurrence, prognostic factors, and toxicity in the curative treatment using image-guided radiotherapy (RT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this retrospective review, we identified 53 patients who were treated at a single center with external beam radiotherapy and brachytherapy with or without concomitant chemotherapy from 2000 to 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>With a median follow-up of 64.5 months, the Kaplan-Meier 2-, 5-, and 7-year overall survival (OS) was found to be 74.8%, 62.8%, and 58.9%, respectively. Local and distant control were 67.8%, 65.0%, and 65.0% and 74.4%, 62.6%, and 62.6% at 2, 5, and 7 years, respectively. In univariate Cox proportional hazards ratio analysis, OS was significantly correlated to FIGO stage (hazard ratio [HR] 1.78, p = 0.042), postoperative RT (HR 0.41, p = 0.044), and concomitant chemotherapy (HR 0.31, p = 0.009). Local control rates were superior when an equivalent dose in 2-Gy fractions (EQD2) of \u2a7e65 Gy was delivered (HR 0.216, p = 0.028) and with the use of concurrent chemotherapy (HR 0.248, p = 0.011). Not surprisingly, local control was inferior for patients with a higher TNM stage (HR 3.303, p = 0.027). Minimal toxicity was observed with no patients having documentation of high-grade toxicity (CTCAE grade 3+).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In treatment of vaginal cancer, high-dose RT in combination with brachytherapy is well tolerated and results in effective local control rates, which significantly improve with an EQD2(\u03b1\/\u03b2=10) \u2a7e65 Gy. Multivariate analyses revealed concomitant chemotherapy was a positive prognostic factor for overall and progression-free survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03008916211056369","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T01:20:00Z","timestamp":1635816000000},"page":"112-120","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Vaginal cancer treated with curative radiotherapy with or without concomitant chemotherapy: oncologic outcomes and prognostic factors"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7087-9581","authenticated-orcid":false,"given":"Eva","family":"Meixner","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany"},{"name":"Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany"},{"name":"National Center for Tumor Diseases (NCT), Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Arians","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany"},{"name":"Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany"},{"name":"National Center for Tumor Diseases (NCT), Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Bougatf","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany"},{"name":"Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany"},{"name":"National Center for Tumor Diseases (NCT), Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Line","family":"Hoeltgen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany"},{"name":"Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany"},{"name":"National Center for Tumor Diseases (NCT), Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany"},{"name":"Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany"},{"name":"National Center for Tumor Diseases (NCT), Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5355-3173","authenticated-orcid":false,"given":"Kristin","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany"},{"name":"Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany"},{"name":"National Center for Tumor Diseases (NCT), Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Domschke","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Heidelberg University Hospital, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Wallwiener","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Heidelberg University Hospital, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan W.","family":"Lischalk","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix K.F.","family":"Kommoss","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute of 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