{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:16:21Z","timestamp":1777918581448,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To describe in non-small cell lung cancer (NSCLC) the impact of visceral pleural invasion (VPI) and of tumor sizing assessed at computed tomography (CT) on the agreement between clinical-radiological and pathological T staging and its prognostic value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Patients affected by NSCLC treated by surgery in the period from January 2017 to September 2020 were retrospectively evaluated. Exclusion criteria were: (1) baseline CT not performed in our hospital; (2) failure of software segmentation at CT of the primary lesion. Clinical-radiological T (cT) was assessed at baseline CT, evaluating in particular T size by semi-automatic tool and VPI (cVPI) visually. Pathological T (pT) and VPI (pVPI) were recorded by pathological report and obtained after formalin-fixation and eventual elastic stain on surgical specimen. The agreement between cT and pT was evaluated by calculating the weighted kappa by Cohen (\u03ba\n                      <jats:sub>w<\/jats:sub>\n                      ); the association between progression free survival (PFS) with both cT and pT was assessed by the Cox regression analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The study included 84 NSCLC in 82 patients (median age 71 years, IQR 63-76 years; females 22\/82, 27%). The agreement between cT and pT was poor (\u03ba\n                      <jats:sub>w<\/jats:sub>\n                      0.302, 95%CI 0.158-0.447). The main causes of disagreement were CT oversizing (21%) and false positive cVPI (29%). A significant association was found between PFS and pT2-T3 (HR 2.75, 95%CI 1.21-6.25, p=0.015) but not with cT2-T3 (not retained in the model).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>False positive cVPI and oversizing at CT are causes of disagreement between cT and pT in around one-third of resected NSCLC. PFS was significantly associated with pT but not with cT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03008916221083702","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T03:02:17Z","timestamp":1648436537000},"page":"215-223","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Role of visceral pleural invasion and tumor sizing at CT of resected NSCLC in clinical-radiological and pathological T agreement"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2794-5237","authenticated-orcid":false,"given":"Davide","family":"Colombi","sequence":"first","affiliation":[{"name":"Department of Radiological Functions, Radiology Unit, \u201cGuglielmo da Saliceto\u201d Hospital, Piacenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Petrini","sequence":"additional","affiliation":[{"name":"Department of Radiological Functions, Radiology Unit, \u201cGuglielmo da Saliceto\u201d Hospital, Piacenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fausto","family":"Rapacioli","sequence":"additional","affiliation":[{"name":"Department of Radiological Functions, Radiology Unit, \u201cGuglielmo da Saliceto\u201d Hospital, Piacenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio C.","family":"Bodini","sequence":"additional","affiliation":[{"name":"Department of Radiological Functions, Radiology Unit, \u201cGuglielmo da Saliceto\u201d Hospital, Piacenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Chiesa","sequence":"additional","affiliation":[{"name":"Emergency Department, Pneumology Unit, \u201cGuglielmo da Saliceto\u201d Hospital, Piacenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cosimo","family":"Franco","sequence":"additional","affiliation":[{"name":"Emergency Department, Pneumology Unit, \u201cGuglielmo da Saliceto\u201d Hospital, Piacenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Citterio","sequence":"additional","affiliation":[{"name":"Department of Oncology-Hematology, Oncology Unit, \u201cGuglielmo da Saliceto\u201d Hospital, Piacenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Cavanna","sequence":"additional","affiliation":[{"name":"Department of Oncology-Hematology, Oncology Unit, \u201cGuglielmo da Saliceto\u201d Hospital, Piacenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano","family":"Zangrandi","sequence":"additional","affiliation":[{"name":"Department of Oncology-Hematology, Pathology Unit, \u201cGuglielmo da Saliceto\u201d Hospital, Piacenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Sverzellati","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery (DiMeC), Radiological Sciences, University of Parma, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Michieletti","sequence":"additional","affiliation":[{"name":"Department of Radiological Functions, Radiology Unit, \u201cGuglielmo da Saliceto\u201d Hospital, Piacenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,3,28]]},"reference":[{"key":"bibr1-03008916221083702","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2015.09.009"},{"key":"bibr2-03008916221083702","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx222"},{"key":"bibr3-03008916221083702","first-page":"447","volume":"19","author":"Colombi D","year":"2013","journal-title":"Diagnostic Interv 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