{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:16:42Z","timestamp":1777918602190,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Pleural mesothelioma is a rare cancer with a dismal prognosis and few therapeutic options, especially in the pretreated setting. Immunotherapy with checkpoint inhibitors as single agents yielded interesting results in refractory pleural mesothelioma, achieving a response rate between 10-20%, median progression-free survival of 2-5 months and median overall survival of 7-13 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods:<\/jats:title>\n                    <jats:p>A retrospective, multi-institutional study of pleural mesothelioma patients treated with nivolumab in second and further line was performed. The endpoints of the study are response rate, disease control rate, progression free survival and overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Sixty-five patients with pleural mesothelioma treated with nivolumab in second and further line were enrolled at seven Italian institutions. The response rate was 8%, disease control rate was 37%, median progression free survival was 5.7 months (95% CI: 2.9-9.0) and median overall survival was 11.1 (95% CI 6.2-19.9) months. A higher neutrophils and neutrophils to lymphocytes ratio at baseline were associated with worse prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Nivolumab as a single agent is fairly active in a cohort of unselected pretreated pleural mesothelioma patients. Further investigations on clinical and translational factors are needed to define which patient might benefit most from nivolumab treatment in pleural mesothelioma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03008916241229287","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T04:15:06Z","timestamp":1708316106000},"page":"168-173","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Nivolumab in pretreated pleural mesothelioma: Results from an observational real-world study of patients treated within the AIFA 5% Fund"],"prefix":"10.1177","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0663-244X","authenticated-orcid":false,"given":"Luigi","family":"Cerbone","sequence":"first","affiliation":[{"name":"Mesothelioma Unit AO SS, Antonio e Biagio e Cesare Arrigo, Alessandria, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Delfanti","sequence":"additional","affiliation":[{"name":"Mesothelioma Unit AO SS, Antonio e Biagio e Cesare Arrigo, Alessandria, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Crivellari","sequence":"additional","affiliation":[{"name":"Mesothelioma Unit AO SS, Antonio e Biagio e Cesare Arrigo, Alessandria, Italy"},{"name":"Projects, Investigation and Innovation Unit, Ospedale Michele e Pietro Ferrero, Verduno, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonina Maria","family":"De Angelis","sequence":"additional","affiliation":[{"name":"Mesothelioma Unit AO SS, Antonio e Biagio e Cesare Arrigo, Alessandria, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9226-8861","authenticated-orcid":false,"given":"Laura","family":"Mazzeo","sequence":"additional","affiliation":[{"name":"Medical Oncology Department 1, Fondazione IRCCS - Istituto Nazionale Dei Tumori, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Proto","sequence":"additional","affiliation":[{"name":"Medical Oncology Department 1, Fondazione IRCCS - Istituto Nazionale Dei Tumori, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7169-5343","authenticated-orcid":false,"given":"Mario","family":"Occhipinti","sequence":"additional","affiliation":[{"name":"Medical Oncology Department 1, Fondazione IRCCS - Istituto Nazionale Dei Tumori, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Lo Russo","sequence":"additional","affiliation":[{"name":"Medical Oncology Department 1, Fondazione IRCCS - Istituto Nazionale Dei Tumori, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Dellepiane","sequence":"additional","affiliation":[{"name":"Lung Cancer Unit, Oncology Unit 2, IRCCS Ospedale Policlinico San Martino, Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Biello","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Alabiso","sequence":"additional","affiliation":[{"name":"Oncology Unit 2, Presidio Ospedaliero S. Giovanni Bosco, Azienda Sanitaria Locale Citt\u00e0 Di Torino, Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Verderame","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit, Azienda Ospedaliera Ospedali Riuniti PO Vincenzo Cervello, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Gauna","sequence":"additional","affiliation":[{"name":"Oncology Unit, Ospedale Degli Infermi, Ponderano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"De Simone","sequence":"additional","affiliation":[{"name":"Clinical Oncology Department, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Cuppone","sequence":"additional","affiliation":[{"name":"Pre-Authorisation Department, Italian Medicines Agency, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Petraglia","sequence":"additional","affiliation":[{"name":"Pre-Authorisation Department, Italian Medicines Agency, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Pasello","sequence":"additional","affiliation":[{"name":"Medical Oncology 2, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy 12Department of Surgery, Oncology and Gastroenterology, University of Padua, Italy"},{"name":"Department of Surgery, Oncology and Gastroenterology, University of Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni Luca","family":"Ceresoli","sequence":"additional","affiliation":[{"name":"Medical Oncology, Humanitas Gavazzeni, Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina Chiara","family":"Garassino","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Chicago Comprehensive Cancer Center, University of Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valter","family":"Torri","sequence":"additional","affiliation":[{"name":"Clinical Oncology Department, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Grosso","sequence":"additional","affiliation":[{"name":"Mesothelioma Unit AO SS, Antonio e Biagio e Cesare Arrigo, Alessandria, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"key":"bibr1-03008916241229287","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.20360"},{"key":"bibr2-03008916241229287","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.11.005"},{"key":"bibr3-03008916241229287","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2014.03.006"},{"key":"bibr4-03008916241229287","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101432"},{"key":"bibr5-03008916241229287","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00404-6"},{"key":"bibr6-03008916241229287","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30765-4"},{"key":"bibr7-03008916241229287","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.05.038"},{"key":"bibr8-03008916241229287","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-0103"},{"key":"bibr9-03008916241229287","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.09.009"},{"key":"bibr10-03008916241229287","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2022.100644"},{"key":"bibr11-03008916241229287","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2022.103639"},{"key":"bibr12-03008916241229287","first-page":"1530","volume":"22","author":"Fennell DA","year":"2021","journal-title":"Oncol"},{"key":"bibr13-03008916241229287","unstructured":"Fondo Nazionale AIFA. Agenzia Italiana del Farmaco, https:\/\/www.aifa.gov.it\/fondo-nazionale-aifa (accessed, 6 July 2023)"},{"key":"bibr14-03008916241229287","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.04.034"},{"key":"bibr15-03008916241229287","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-19-686"},{"key":"bibr16-03008916241229287","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.15_suppl.8569"},{"key":"bibr17-03008916241229287","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2020.38.15_suppl.9052"},{"key":"bibr18-03008916241229287","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14061498"},{"key":"bibr19-03008916241229287","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1177\/03008916211012320","volume":"107","author":"Crivellari S","year":"2021","journal-title":"Tumori"},{"key":"bibr20-03008916241229287","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2012.03.011"},{"key":"bibr21-03008916241229287","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-31448-4"},{"key":"bibr22-03008916241229287","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy086"},{"key":"bibr23-03008916241229287","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2022.08.019"},{"key":"bibr24-03008916241229287","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.8506"},{"key":"bibr25-03008916241229287","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.17_suppl.LBA8505"},{"key":"bibr26-03008916241229287","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00043-6"},{"key":"bibr27-03008916241229287","first-page":"4","volume":"108","author":"Cerbone L","year":"2022","journal-title":"Tumori"}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03008916241229287","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03008916241229287","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03008916241229287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:43:09Z","timestamp":1777660989000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03008916241229287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,19]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1177\/03008916241229287"],"URL":"https:\/\/doi.org\/10.1177\/03008916241229287","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,19]]}}}