{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:17:26Z","timestamp":1777918646892,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The increasing incidence, rapidly evolving classification, rarity and heterogeneity of neuroendocrine neoplasms (NENs) pose challenges to NEN registration including difficulty in distinguishing neuroendocrine carcinoma (NEC) and neuroendocrine tumours (NETs). Thus, in Italy a higher NEC incidence was reported. Focusing on gastroenteropancreatic (GEP) NEN, we aimed to review GEP NEN, and in particular cases of neuroendocrine carcinoma, not otherwise specified (NOS) and estimate the incidence of NEN, NET and NEC of the GEP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We launched a pilot study examining cases of neuroendocrine carcinomas NOS (ICD-O3 code 8246) of GEP incidents in the years 2012-2020. Cancer registries (CRs) reviewed information included in the pathology report regarding differentiation and tumour cells proliferation to decide whether to confirm the case as neuroendocrine carcinoma NOS or register it as NET or NEC. After the review, we estimated the GEP NEN, NET and NEC incidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Nine CRs contributed to the pilot study. After review, in all CRs, only 31% of GEP NOS neuroendocrine carcinomas were confirmed; 50% were recoded as NETs, and approximately 17% of cases were non-NENs. The IR of GEP NENs was 2.99\/100,000, and the incidence of NETs was higher than that of NECs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>After the review, the incidence of GEP NEN, NET and NEC in the eight Italian CRs involved was comparable to that reported in other European countries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Impact:<\/jats:title>\n                    <jats:p>Our results confirmed that heterogeneity of cancer registries in the registration of NEN requires collaborative work to define and promote a standard definition to be extended to all Italian registries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03008916251317128","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:03Z","timestamp":1740614403000},"page":"133-138","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Towards a better registration of neuroendocrine neoplasms: The results of the Italian retrospective population-based study"],"prefix":"10.1177","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8220-9833","authenticated-orcid":false,"given":"Annalisa","family":"Trama","sequence":"first","affiliation":[{"name":"Evaluative Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Cuccaro","sequence":"additional","affiliation":[{"name":"Puglia Cancer Registry, Section of Local Health Authority Barletta-Andria-Trani, Barletta, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Damiani","sequence":"additional","affiliation":[{"name":"Department of Pathology, Provincial Hospital of Bolzano (SABES-ASDAA), Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversit\u00e4t, via Lorenz B\u00f6hler, 5, 39100 Bolzano-Bozen, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"Evaluative Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Panzuto","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Translational Medicine, Digestive Disease Unit, Sant\u2019 Andrea University Hospital, ENETS Center of Excellence, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Fazio","sequence":"additional","affiliation":[{"name":"Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, IRCCS European Institute of Oncology (IEO), Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Carone","sequence":"additional","affiliation":[{"name":"Puglia Cancer Registry, Section of Local Health Authority Taranto, Taranto, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Giovanna","family":"Burgio Lo Monaco","sequence":"additional","affiliation":[{"name":"Puglia Cancer Registry, Coordination Centre, Strategic Regional Agency for Health and Social Care - Puglia, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossella","family":"Bruni","sequence":"additional","affiliation":[{"name":"Puglia Cancer Registry, Coordination Centre, Strategic Regional Agency for Health and Social Care - Puglia, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adele","family":"Caldarella","sequence":"additional","affiliation":[{"name":"Tuscany Cancer Registry, Clinical Epidemiology Unit Institute for Cancer Research, Prevention and Clinical Network, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Roselli","sequence":"additional","affiliation":[{"name":"Tuscany Cancer Registry, Clinical Epidemiology Unit Institute for Cancer Research, Prevention and Clinical Network, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Cortini","sequence":"additional","affiliation":[{"name":"Tuscany Cancer Registry, Clinical Epidemiology Unit Institute for Cancer Research, Prevention and Clinical Network, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalba","family":"Amodio","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Cancer Registry Unit, Azienda Ospedaliera Universitaria Policlinico, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Mazzucco","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Cancer Registry Unit, Azienda Ospedaliera Universitaria Policlinico, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Leite","sequence":"additional","affiliation":[{"name":"Cancer Registry of Umbria, Punto Zero, Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Lupi","sequence":"additional","affiliation":[{"name":"School of Public Health, Department of Medicine, University of Perugia, Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maddalena","family":"Baracco","sequence":"additional","affiliation":[{"name":"Veneto Tumour Registry, Epidemiological Department, Azienda Zero, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Carpin","sequence":"additional","affiliation":[{"name":"Veneto Tumour Registry, Epidemiological Department, Azienda Zero, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Dal Cin","sequence":"additional","affiliation":[{"name":"Veneto Tumour Registry, Epidemiological Department, Azienda Zero, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annarita","family":"Fiore","sequence":"additional","affiliation":[{"name":"Veneto Tumour Registry, Epidemiological Department, Azienda Zero, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Memo","sequence":"additional","affiliation":[{"name":"Veneto Tumour Registry, Epidemiological Department, Azienda Zero, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Guzzinati","sequence":"additional","affiliation":[{"name":"Veneto Tumour Registry, Epidemiological Department, Azienda Zero, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonietta Alfia Maria","family":"Torrisi","sequence":"additional","affiliation":[{"name":"Cancer Registry Catania-Messina-Enna, G. Rodolico \u2013 San Marco Polyclinic University Hospital, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonina","family":"Torrisi","sequence":"additional","affiliation":[{"name":"Cancer Registry Catania-Messina-Enna, G. Rodolico \u2013 San Marco Polyclinic University Hospital, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margherita","family":"Ferrante","sequence":"additional","affiliation":[{"name":"Cancer Registry Catania-Messina-Enna, G. Rodolico \u2013 San Marco Polyclinic University Hospital, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Pesce","sequence":"additional","affiliation":[{"name":"ASL Caserta - U.O.C. Monitoraggio rischio ambientale e Registro Tumori, Caserta, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Sessa","sequence":"additional","affiliation":[{"name":"ASL Caserta - U.O.C. 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