{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:17:31Z","timestamp":1777918651237,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The clinical significance of fibroblast growth factor receptors (FGFRs) and their ligands in hepatocellular carcinoma (HCC) is extensively studied. Recently, regulation of voltage-gated sodium channels by FGFs in cancer has been reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods:<\/jats:title>\n                    <jats:p>\n                      We investigated the relationship between FGF family genes and voltage-gated sodium channel genes (SCN) using three independent microarray and RNA-seq cohorts HCC patients.\n                      <jats:italic>In vitro<\/jats:italic>\n                      validation of 100 tissues of HCC patients with 50 control samples was performed. Statistical validation included the Wilcoxon test, Mann-Whitney U-test, correlation, Kaplan-Meier survival, and univariate and multivariate Cox regression survival analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result:<\/jats:title>\n                    <jats:p>\n                      The initial analysis of intracrine FGF (iFGF) ligands showed dysregulation of iFGF genes in HCC with strong association with each other in all datasets. According to\n                      <jats:italic>in vitro<\/jats:italic>\n                      analysis, overexpression of\n                      <jats:italic>FGF14<\/jats:italic>\n                      was also observed in HCC patients suggesting potential role of\n                      <jats:italic>FGF14<\/jats:italic>\n                      in HCC.\n                    <\/jats:p>\n                    <jats:p>\n                      Furthermore, network analysis showed that\n                      <jats:italic>FGF14<\/jats:italic>\n                      was strongly interacting with SCN genes. Interestingly, SCN genes were also found in HCC samples with a positive correlation with\n                      <jats:italic>FGF14<\/jats:italic>\n                      expression. The clinical analysis showed that\n                      <jats:italic>FGF14<\/jats:italic>\n                      ,\n                      <jats:italic>SCN2A<\/jats:italic>\n                      and\n                      <jats:italic>SCN11A<\/jats:italic>\n                      are significantly associated with better disease-free survival, whereas multivariate regression analysis showed\n                      <jats:italic>SCN11A<\/jats:italic>\n                      as an independent predictor of disease-free survival in HCC patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      The dysregulation of\n                      <jats:italic>FGF14<\/jats:italic>\n                      and SCN family genes suggests a new molecular mechanism in the regulation of HCC. Furthermore,\n                      <jats:italic>SCN11A<\/jats:italic>\n                      was identified as a possible predictor for disease-free survival in HCC. Investigating these gene families using clinical studies may lead to new therapeutic approaches for HCC treatment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03008916251334565","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T01:58:56Z","timestamp":1746583136000},"page":"238-245","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Increased expression of FGF14 and SCN2A\/SCN11A is associated with better survival of HCC patients"],"prefix":"10.1177","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1760-3516","authenticated-orcid":false,"given":"Walizeb","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Biosciences, COMSATS University, Islamabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hifsa","family":"Younas","sequence":"additional","affiliation":[{"name":"Department of Biosciences, COMSATS University, Islamabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Zeb","sequence":"additional","affiliation":[{"name":"Department of Biosciences, COMSATS University, Islamabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Faraz Arshad","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Biosciences, COMSATS University, Islamabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5998-787X","authenticated-orcid":false,"given":"Muhammad","family":"Saeed","sequence":"additional","affiliation":[{"name":"Department of Biosciences, COMSATS University, Islamabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9190-4360","authenticated-orcid":false,"given":"Farhan","family":"Haq","sequence":"additional","affiliation":[{"name":"Department of Biosciences, COMSATS University, Islamabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acr.2020.10.001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113242"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-020-01709-5"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.172920"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.176"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm501981g"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.7b00399"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222413541"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.742903"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-022-02112-4"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01111"},{"key":"e_1_3_2_13_2","article-title":"Comprehensive analysis to identify the encoded gens of sodium channels as a prognostic biomarker in hepatocellular carcinoma","volume":"12","author":"Yan Y","year":"2022","unstructured":"Yan Y, He W, Chen Y, et al. 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