{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:02:07Z","timestamp":1780081327395,"version":"3.54.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To analyze the central lymph node metastasis (CLNM) rates of patients who underwent prophylactic central lymph node dissection (pCLND) with total thyroidectomy for cT1-2N0 papillary thyroid cancer in our clinic, to evaluate the conditions associated with lymph node metastasis, and to examine the necessity of pCLND in these patient groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study includes a retrospective review of the medical data of patients who underwent bilateral\/unilateral central lymph node dissection (CLND) (b\/uCLND) with total thyroidectomy in our center between 2013 and 2021, whose fine needle aspiration biopsy result was reported as malignant, who were detected as cT1a-1b-2N0 on thyroid and neck ultrasonography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the 251 patients included in the study, 63 (25%) had CLNM (49 (19.5%) ipsilateral and 14 (5.5%) had contralateral CLNM). Twenty-two (20.1%) of 109 patients with cT1a, 30 (28.3%) of 106 patients with cT1b, and 11 (30.5%) of 36 patients with cT2 had CLNM, and metastasis rates increased with increasing cT category. CLNM rates increased with increasing pT category (p=0.005). CLNM was present in 21 (38.8%) of 54 patients (21.5%) with collision tumors, and metastasis rates increased significantly compared to the presence of a single histopathologic tumor (p=0.006). CLNM rates were higher in patients with multicentric tumor localization than in those with unicentric localization (p=0.006).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Multicentricity, bilaterality, capsule invasion, collision tumors and tumors larger than 1 cm increase the risk of CLNM. uCLND for tumors larger than 1 cm, bCLND for tumors larger than 2 cm can be considered. We believe that patients with unilateral CLNM also have an increased risk of contralateral metastasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03008916251334884","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T23:54:08Z","timestamp":1748994848000},"page":"302-309","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Ongoing discussion: Is prophylactic central neck dissection necessary in\n                    <sub>c<\/sub>\n                    T\n                    <sub>1a-b,2<\/sub>\n                    N\n                    <sub>0<\/sub>\n                    papillary thyroid cancer?"],"prefix":"10.1177","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9445-6129","authenticated-orcid":false,"given":"\u00d6mer","family":"Bay\u0131r","sequence":"first","affiliation":[{"name":"Department of Otolaryngology and Head &amp; Neck Surgery, Etlik City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latif","family":"Akan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head &amp; Neck Surgery, Etlik City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed","family":"K\u0131z\u0131lg\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Etlik City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bekir","family":"U\u00e7an","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Etlik City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevilay","family":"Karahan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Hacettepe University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6khan","family":"Topta\u015f","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head &amp; Neck Surgery, Etlik City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eevket","family":"Aksoy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head &amp; Neck Surgery, Etlik City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra Nur","family":"Bay\u0131r","sequence":"additional","affiliation":[{"name":"Department of Pathology, Etlik City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed Erkam","family":"Sencar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Endocrinology and Metabolism Clinic, At\u0131l\u0131m University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erman","family":"\u00c7akal","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Etlik City Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcleser","family":"Saylam","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head &amp; Neck Surgery, Faculty of Medicine, Lokman Hekim University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Hakan","family":"Korkmaz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head &amp; Neck Surgery, Private Clinic, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_3_2_3_2","unstructured":"T.C. 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