{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:17:47Z","timestamp":1777918667697,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"This study was funded by the Italian Ministry of Health - RICERCA FINALIZZATA 2018.","award":["grant number RF-2018-12365530"],"award-info":[{"award-number":["grant number RF-2018-12365530"]}]},{"name":"the AIRC IG and by the Italian Ministry of Health (Ricerca Corrente)","award":["grant number 28893"],"award-info":[{"award-number":["grant number 28893"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>An indirect approach was applied to the case-study of thyroid cancer (TC) and melanoma of the skin (MS) in Italy to identify health services (HS) for cancer patients and to enable cost estimation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods:<\/jats:title>\n                    <jats:p>Within the Epicost-2 project, a self-controlled crossover design analysed TC and MS 2018 prevalent cases from Italian cancer registries. Controls (1:1) were matched to cases 18-6 months prior to diagnosis; increases between cases and controls in potentially cancer-related HS claims (P\u2a7d5%) were identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Validation:<\/jats:title>\n                    <jats:p>Oncology and clinical experts validated cancer-related HS lists using statistical, clinical, and economic criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The approach identified 202 and 333 cancer-related HS codes for TC and MS, respectively, aligned with clinical pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>The indirect approach reduced validation workload by 75% versus direct one.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The approach identifies the costs of cancer care that could also be reproduced in other countries with consistent results, and the approach applied to other cancers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03008916251353109","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T06:57:21Z","timestamp":1757055441000},"page":"400-412","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["An indirect approach to identify the healthcare services for thyroid and melanoma cancer patients in Italy: Epicost-2 project"],"prefix":"10.1177","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6686-6905","authenticated-orcid":false,"given":"Sandra","family":"Mallone","sequence":"first","affiliation":[{"name":"National Center for 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