{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T01:01:54Z","timestamp":1778029314024,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate to describe outcomes of conization or expectant management for women with persistent (&gt;24 months) low-grade cervical intra-epithelial neoplasia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This is a retrospective analysis focusing on five-year outcomes after persistent, histologically confirmed, low-grade cervical intra-epithelial neoplasia undergoing conization or expectant management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Charts of 219 women with persistent low-grade cervical lesions were retrieved. Overall, 98 (44.7%) and 121 (55.3%) women had conization and observation, respectively. Patients receiving conization were older than patients having observation (43 (range, 24-77) vs. 39 (range, 25-68) years; p=0.013). Focusing on the group of patients receiving conization, 16 (16.3%) women were diagnosed with CIN2+. The five-year risk of secondary conization was 5% (n=5). Focusing on patients having observation (n=121), 18 (14.8%) patients received conization, after a median of 16.5 (range, 6-30) months. Seven (5.8%) and 11 (9.1%) patients were diagnosed with persistent CIN1 and CIN2+, respectively. Not fully visible squamous-columnar junction at colposcopic examination (p=0.035) was associated with CIN2+ occurrence. No invasive cancer was observed<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Conization for persistent low-grade cervical intra-epithelial neoplasia revealed \u201coccult\u201d CIN2+ in 16% of patients. However, expectant management appears safe and effective in this context, in women with fully visible squamous columnar junction. The decision between conization and expectant management should be discussed on an individual basis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03008916251395597","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T08:35:27Z","timestamp":1768984527000},"page":"75-82","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Expectant management or conization for persistent low-grade cervical intraepithelial neoplasia: Analysis of 5-year outcomes"],"prefix":"10.1177","volume":"112","author":[{"given":"Giorgio","family":"Bogani","sequence":"first","affiliation":[{"name":"Gynecologic Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Sopracordevole","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Corso","sequence":"additional","affiliation":[{"name":"Division of Breast Surgery, European Institute of Oncology IEO, IRCCS, Milan, Italy"},{"name":"Department of Oncology and Hematology, University of Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Vizza","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, Department of Experimental Clinical Oncology, IRCSS-Regina Elena National Cancer Institute, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Scollo","sequence":"additional","affiliation":[{"name":"Kore University of Enna, Cannizzaro Hospital, Department of Obstetrics and Gynecology, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Giannini","sequence":"additional","affiliation":[{"name":"Unit of Gynecology, Sant\u2019Andrea Hospital, Department of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violante","family":"Di Donato","sequence":"additional","affiliation":[{"name":"University Sapienza of Roma, Department of Obstetrics and Gynecology, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Ciavattini","sequence":"additional","affiliation":[{"name":"Gynecologic Section, Woman\u2019s Health Sciences Department, Polytechnic University of Marche, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"De Vincenzo","sequence":"additional","affiliation":[{"name":"Diapartimento Ostetricia e Ginecologia, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Gardella","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia","family":"Sorbi","sequence":"additional","affiliation":[{"name":"Department of Experimental, Clinical and Biomedical Sciences \"Mario Serio\", University of Florence, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Fambrini","sequence":"additional","affiliation":[{"name":"Department of Experimental, Clinical and Biomedical Sciences \"Mario Serio\", University of Florence, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Ghezzi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, \u2018Filippo Del Ponte\u2019 Hospital, University of Insubria, Varese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jvan","family":"Casarin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, \u2018Filippo Del Ponte\u2019 Hospital, University of Insubria, Varese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Petrillo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology. University of Sassari, Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Borso","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy"},{"name":"Department of Biomedical Science for Health, University of Milan, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3503-5010","authenticated-orcid":false,"given":"Noemi","family":"Tonti","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy"},{"name":"University Sapienza of Roma, Department of Obstetrics and Gynecology, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1811-209X","authenticated-orcid":false,"given":"Valentina","family":"Chiappa","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Raspagliesi","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Vizzielli","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, Obstetrics and Gynecology Clinic, Ospedale Santa Maria Della Misericordia, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy"},{"name":"Department of Medicine (DMED), University of Udine, Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.3.252"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2022-070135"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16142541"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2023.08.369"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25635"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000242"},{"key":"e_1_3_2_8_2","first-page":"632","article-title":"Repeat low-grade squamous intraepithelial cytology with unsatisfactory colposcopy treated by the loop electrosurgical excision procedure: a retrospective study","volume":"31","author":"Liu Y","year":"2010","unstructured":"Liu Y, Li C, Wang J, et al. 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