{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:18:14Z","timestamp":1777918694403,"version":"3.51.4"},"reference-count":58,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Secretariat of Science, Humanities, Technology, and Innovation"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, and asparaginase (ASNase) is a key component of its treatment. However, ASNase is frequently associated with adverse events (AEs), such as pancreatitis and hypersensitivity reactions particularly with the\n                      <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                      derived formulation (L-Asp) which may be influenced by nutritional status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the association between protein-energy malnutrition (PEM) and the incidence of L-Asp induced AEs in children with ALL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A prospective observational cohort with a nested case-control comparative analysis was conducted in 91 pediatric patients treated with L-Asp. Anthropometric measurements, anti-L-Asp antibody detection, and AEs occurrence were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Eighteen patients (19.8%) developed AEs: six pancreatitis and 12 hypersensitivity reactions. Of these, 14 (77.7%) had PEM. PEM was significantly associated with AEs (OR = 12.22; p = 0.02). Pancreatitis occurred mostly during induction and affected 83.3% of PEM patients. Hypersensitivity reactions were more frequent during reinduction and were associated with anti-L-Asp antibodies in all cases, 75% of which had PEM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>PEM was significantly linked to increased risk of L-Asp related toxicity, suggesting nutritional status as a modifiable factor. Early identification and correction of PEM may improve the safety profile of L-Asp in pediatric ALL therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03008916251404280","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T09:45:12Z","timestamp":1768556712000},"page":"40-50","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Nutritional status as a risk factor for adverse events associated with L-Asparaginase in children with acute lymphoblastic leukemia"],"prefix":"10.1177","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5927-4992","authenticated-orcid":false,"given":"Jes\u00fas Alonso","family":"G\u00e1ndara-Mireles","sequence":"first","affiliation":[{"name":"Genomics Academy, National Polytechnic Institute, CIIDIR-Durango Unit, Durango, Mexico"},{"name":"Latin American Network for the Implementation and Validation of Pharmacogenomic Clinical Guidelines (RELIVAF-CYTED), Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Loera Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Genomics Academy, National Polytechnic Institute, CIIDIR-Durango Unit, Durango, Mexico"},{"name":"Latin American Network for the Implementation and Validation of Pharmacogenomic Clinical Guidelines (RELIVAF-CYTED), Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismael","family":"Lares-Assef","sequence":"additional","affiliation":[{"name":"Genomics Academy, National Polytechnic Institute, CIIDIR-Durango Unit, Durango, Mexico"},{"name":"Latin American Network for the Implementation and Validation of Pharmacogenomic Clinical Guidelines (RELIVAF-CYTED), Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elio Aar\u00f3n","family":"Reyes Espinoza","sequence":"additional","affiliation":[{"name":"Pediatric Hemato-Oncology Service, State Cancer Center (CECAN), Durango, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes Patricia","family":"C\u00f3rdova Hurtado","sequence":"additional","affiliation":[{"name":"Pediatric Hemato-Oncology Service, State Cancer Center (CECAN), Durango, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio Cesar","family":"Grijalva \u00c1vila","sequence":"additional","affiliation":[{"name":"Genomics Academy, National Polytechnic Institute, CIIDIR-Durango Unit, Durango, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Villanueva Fierro","sequence":"additional","affiliation":[{"name":"Genomics Academy, National Polytechnic Institute, CIIDIR-Durango Unit, Durango, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Patr\u00f3n Romero","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Psychology, Autonomous University of Baja California, Tijuana, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horacio","family":"Almanza Reyes","sequence":"additional","affiliation":[{"name":"Latin American Network for the Implementation and Validation of Pharmacogenomic Clinical Guidelines (RELIVAF-CYTED), Santiago, Chile"},{"name":"Faculty of Medicine and Psychology, Autonomous University of Baja California, Tijuana, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-63528-0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13092256"},{"key":"e_1_3_3_4_2","first-page":"91","article-title":"El ni\u00f1o de poblaci\u00f3n abierta con c\u00e1ncer en M\u00e9xico. 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