{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T15:06:28Z","timestamp":1781708788047,"version":"3.54.5"},"reference-count":24,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Breast cancer is a leading malignancy among women worldwide, significantly affecting physical, psychological, and sexual well-being. Surgical options such as breast conservation surgery (BCS) and mastectomy have distinct implications on patients' quality of life. This study aimed to compare health-related quality of life (HRQoL) and sexual functioning in breast cancer patients undergoing BCS or mastectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A prospective observational study was conducted over a 10-month period at a tertiary care hospital. Sixty-five breast cancer patients aged 20\u201350 years, who underwent either BCS (n=33) or mastectomy (n=32), were enrolled. Data were collected on baseline characteristics and HRQoL and sexual functioning were assessed using the EORTC QLQ-BR42 and Female Sexual Function Index (FSFI) questionnaires.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>BCS patients reported significantly better scores in FSFI domains such as desire, lubrication, orgasm, and satisfaction (p&lt;0.05), with a higher final FSFI score (5.53 \u00b1 1.78) compared to mastectomy patients (3.93 \u00b1 1.06). On the BR42 scale, BCS patients showed better body image and satisfaction scores (p&lt;0.05). No significant differences were observed in systemic side effects, future health worries, and sexuality domains between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Breast conservation surgery patients had better sexual function and quality of life compared to mastectomy patients. These findings underscore the importance of incorporating quality-of-life outcomes in surgical decision-making and preoperative counseling for breast cancer patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03008916261425451","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T06:09:42Z","timestamp":1772431782000},"page":"118-123","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Quality of life and sexual function after breast conservation surgery and mastectomy without reconstruction in South Indian patients"],"prefix":"10.1177","volume":"112","author":[{"given":"Silviya","family":"Jenifer","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0249-4197","authenticated-orcid":false,"given":"Sneha","family":"Raja","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1853-4310","authenticated-orcid":false,"given":"Narmatha","family":"Rajarathinam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9785-1634","authenticated-orcid":false,"given":"Jayasutha","family":"Jayram","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manickavasagam","family":"Meenakshisundaram","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,1]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.JAA.0000580524.95733.3d"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v13.i3.209"},{"key":"e_1_3_2_4_2","first-page":"6","article-title":"Breast cancer and associated factors: A review","volume":"8","author":"Ataollahi MR","year":"2015","unstructured":"Ataollahi MR, Sharifi J, Paknahad MR, et al. Breast cancer and associated factors: A review. J Med Life 2015; 8: 6\u201311.","journal-title":"J Med Life"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.21635"},{"key":"e_1_3_2_6_2","unstructured":"Johns Hopkins Medicine. Breast-Conserving Surgery (Lumpectomy). Baltimore MD: Johns Hopkins Medicine https:\/\/www.hopkinsmedicine.org (2023 accessed 5 February 2025)."},{"key":"e_1_3_2_7_2","unstructured":"Czajka ML Pfeifer C. Breast Cancer Surgery. Treasure Island FL: StatPearls Publishing https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK559043\/ (2023 accessed 5 February 2025)."},{"key":"e_1_3_2_8_2","unstructured":"Goethals A Rose J. Mastectomy. Treasure Island (FL): StatPearls Publishing https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK559021\/ (2022 accessed 5 February 2025)"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-020-01591-x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-023-01494-x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-55080-5_18"},{"key":"e_1_3_2_12_2","unstructured":"Rosen R Brown C Heiman J et al. Female Sexual Function Index (FSFI) Scoring Instructions and Calculator https:\/\/www.fsfiquestionnaire.com (2000 accessed 5 February 2025)."},{"key":"e_1_3_2_13_2","unstructured":"European Organisation for Research and Treatment of Cancer (EORTC). EORTC QLQ-BR45: Breast Cancer Module \u2013 Scoring Manual and Questionnaire. Brussels: EORTC https:\/\/qol.eortc.org (2020 accessed 5 February 2025)"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.5152\/tjbh.2014.1919"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijmpo.ijmpo_15_16"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.4103\/0970-0218.91326"},{"key":"e_1_3_2_17_2","article-title":"Factors influencing surgical choices in breast cancer treatment in India: A comparative study of breast-conserving surgery vs mastectomy","volume":"16","author":"Dubey S","year":"2024","unstructured":"Dubey S, Krishnanand K, Shukla Y, et al. Factors influencing surgical choices in breast cancer treatment in India: A comparative study of breast-conserving surgery vs mastectomy. 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