{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T11:23:57Z","timestamp":1794309837904,"version":"4.9.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumori"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background and aim<\/jats:title>\n                    <jats:p>There is limited data on the safety of switching between CDK4\/6i to address toxicity-related permanent discontinuation in patients with HR+\/HER2- advanced breast cancer (ABC).<\/jats:p>\n                    <jats:p>To overcome this issue, this international observational study included consecutive HR+\/HER2- ABC patients treated with CDK4\/6i at two cancer centers, who switched the CDK4\/6i for toxicity. The study aimed to evaluate the safety, feasibility, and clinical impact of this approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1413 patients, 67 (4.5%) switched CDK4\/6i due to toxicity. The median time to switch was three months. Adverse events leading to switch were mainly hematologic and hepatic. Recurrence of the same toxicity occurred in 30% of patients, but with lower severity for neutropenia (p=0.047) and hepatotoxicity (p=0.005). Notably, among the 67 patients who switched CDK4\/6i, only seven (10%) ultimately required permanent discontinuation of the second CDK4\/6i for toxicity, primarily for abemaciclib-induced diarrhea, suggesting that switching may represent a promising strategy to avoid treatment interruption. Median progression-free survival from the start of the first CDK4\/6i was 16.8 months<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, switching CDK4\/6i appears to be a safe and pragmatic strategy to address toxicity-related permanent discontinuation of CDK4\/6i.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03008916261454865","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:14:58Z","timestamp":1785471298000},"page":"473-477","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Switching CDK4\/6 inhibitors to overcome toxicity in HR-positive\/HER2-negative advanced breast cancer"],"prefix":"10.1177","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9805-8117","authenticated-orcid":false,"given":"Chiara","family":"Benvenuti","sequence":"first","affiliation":[{"name":"Department of Medical Oncology and Hematology, Breast Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Viansone","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Gustave Roussy, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Grinda","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Gustave Roussy, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Zeghondy","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Gustave Roussy, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Gaudio","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology, Breast Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Clapis","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7297-052X","authenticated-orcid":false,"given":"Riccardo","family":"Gerosa","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology, Breast Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Canzian","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology, Breast Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Poisson","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Gustave Roussy, Villejuif, 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