{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:02:46Z","timestamp":1777917766707,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1963,5,1]],"date-time":"1963-05-01T00:00:00Z","timestamp":-210556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1963,5]]},"abstract":"<jats:p>Early histological changes in the liver and cancer development in the liver and at other sites have been studied in male and female Buffalo-strain rats ingesting a diet containing N-2-Huorenylacetamide (2-FAA) and a low level of pyridoxine\u2019 H'Cl, A month's delay in the appearance in the liver of mitotic figures in bile-duct cells and in the gradual increase in number of oval or ductal cells in the periportal areas were found in the low-pyridoxine groups when compared to previous studies with diets containing 2-FAA and high in pyridoxine (19).<\/jats:p>\n                  <jats:p>The overall incidence of liver tumors in male and female rats induced by 2-FAA was not influenced by a low level of dietary pyridoxine, but there was a delayed appearance of tumors. Males fed the low pyridoxine-2-FAA diet developed a higher incidence of liver tumors than did females. The highest incidence of ear duct tumors developed in females. These females had the longest survival. The amount of 2-FAA ingested does not appear to have been a deciding factor in the development of tumors in this experiment.<\/jats:p>","DOI":"10.1177\/030089166304900301","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T12:33:19Z","timestamp":1523881999000},"page":"159-171","source":"Crossref","is-referenced-by-count":3,"title":["Influence of a Diet Low in Pyridoxine on Tumorigenesis in Rats Ingesting N-2-Fluorenylacetamide"],"prefix":"10.1177","volume":"49","author":[{"given":"Harold P.","family":"Morris","sequence":"first","affiliation":[{"name":"National Cancer Institute, Bethesda, Maryland, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herschel","family":"Sidransky","sequence":"additional","affiliation":[{"name":"National Cancer Institute, Bethesda, Maryland, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Billie P.","family":"Wagner","sequence":"additional","affiliation":[{"name":"National Cancer Institute, Bethesda, Maryland, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1963,5,1]]},"reference":[{"key":"bibr1-030089166304900301","first-page":"1","volume":"25","author":"Bielschowsky F.","year":"1944","journal-title":"Brit. 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