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Two histologic types of this tumor are known: tipe 1 is sharply circumscribed and is considered similar to so called capillary hypertrophic hemangioma, while type 2, by showing aggressive, infiltrative and anaplastic features, is rather close to angiosarcoma. Clinical and pathological data concerning two cases of type 2 primary hepatic infantile hemangioendothelioma are reported. On the basis of experimental results and epidemiological data on hepatic angiosarcoma of adults, a possible etiopathogenetic relationship with maternal exposure during pregnancy to dangerous environmental factors is postulated.<\/jats:p>","DOI":"10.1177\/030089167506100608","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T12:32:59Z","timestamp":1523881979000},"page":"565-574","source":"Crossref","is-referenced-by-count":4,"title":["Primary Hepatic Infantile Hemangioendothelioma."],"prefix":"10.1177","volume":"61","author":[{"given":"Lucio","family":"Pollice","sequence":"first","affiliation":[{"name":"(Istituto di Anatomia e Istologia Patologica dell'Universit\u00e0, Bari)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Pagliarulo","sequence":"additional","affiliation":[{"name":"(Istituto di Anatomia e Istologia Patologica dell'Universit\u00e0, Bari)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1975,11,1]]},"reference":[{"key":"bibr1-030089167506100608","first-page":"71","volume":"16","author":"Alagille D.","year":"1966","journal-title":"Classification anatomo-clinique \u00e0 propos de six observations. 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