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However, no improvement of survival was noticed: 4 out of 5 stage II patients who died, within 1 year after perfusion, developed a generalized disease. Systemic chemotherapy was administered in 3 patients after perfusion, but they died from distant metastases. The need for an adequate adjuvant treatment added to isolation perfusion is discussed.<\/jats:p>","DOI":"10.1177\/030089167706300307","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T05:44:56Z","timestamp":1523943896000},"page":"289-298","source":"Crossref","is-referenced-by-count":9,"title":["Hyperthermic Isolation-perfusion with Melphalan. A Preliminary Appraisal of Local and General Effects in Malignant Melanoma"],"prefix":"10.1177","volume":"63","author":[{"given":"F. 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