{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:07:03Z","timestamp":1777918023110,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1978,2,1]],"date-time":"1978-02-01T00:00:00Z","timestamp":255139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tumori"],"published-print":{"date-parts":[[1978,2]]},"abstract":"<jats:p>\n                    An increase in the serum copper (Cu\n                    <jats:sup>++<\/jats:sup>\n                    ) level has been described as a sensitive index of disease activity in several hematologic and nonhematologic malignancies. In order to explore the diagnostic value of Cu\n                    <jats:sup>++<\/jats:sup>\n                    compared to other hematochemical parameters frequently abnormal in malignancies, Cu\n                    <jats:sup>++<\/jats:sup>\n                    , serum \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    globulin (\u03b1\n                    <jats:sub>2<\/jats:sub>\n                    ), plasmatic fibrinogen (Fibr), the erythrocyte sedimentation rate (ESR), and serum iron (Fe\n                    <jats:sup>++<\/jats:sup>\n                    ) have been detected and evaluated in 267 patients affected with the following diseases: Hodgkin's lymphoma (HL), non-Hodgkin's Lymphomas (NHL), Acute Leukemias (AL), Chronic Myeloid Leukemia (CML), Chronic Lymphocytic Leukemia (CLL), Myeloma (MM), and Breast Cancer (BC). The best correlation between Cu\n                    <jats:sup>++<\/jats:sup>\n                    increase and disease activity has been found in HL, NHL, AL, and BC. In these diseases, when the considered parameters were compared, Cu\n                    <jats:sup>++<\/jats:sup>\n                    and ESR showed a similar pattern, i.e., a high frequency of abnormalities in active disease. It is concluded that Cu\n                    <jats:sup>++<\/jats:sup>\n                    represents a good complement to some other aspecific parameters in evaluating the activity and diffusion of neoplasias and the therapeutic results, particulary in HL, NHL, AL and BC.\n                  <\/jats:p>","DOI":"10.1177\/030089167806400106","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T12:35:53Z","timestamp":1523882153000},"page":"55-61","source":"Crossref","is-referenced-by-count":22,"title":["The Diagnostic Value of Serum Copper Levels and other Hematochemical Parameters in Malignancies"],"prefix":"10.1177","volume":"64","author":[{"given":"Giovanni","family":"Pizzolo","sequence":"first","affiliation":[{"name":"Istituto di Patologia Speciale Medica e Sezione di Ematologia, Universit\u00e0 degli Studi di Padova, Policlinico di Borgo Roma, Verona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Savarin","sequence":"additional","affiliation":[{"name":"Istituto di Patologia Speciale Medica e Sezione di Ematologia, Universit\u00e0 degli Studi di Padova, Policlinico di Borgo Roma, Verona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Maria","family":"Molino","sequence":"additional","affiliation":[{"name":"Istituto di Patologia Speciale Medica e Sezione di Ematologia, Universit\u00e0 degli Studi di Padova, Policlinico di Borgo Roma, Verona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achille","family":"Ambrosetti","sequence":"additional","affiliation":[{"name":"Istituto di Patologia Speciale Medica e Sezione di Ematologia, Universit\u00e0 degli Studi di Padova, Policlinico di Borgo Roma, Verona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Todeschini","sequence":"additional","affiliation":[{"name":"Istituto di Patologia Speciale Medica e Sezione di Ematologia, Universit\u00e0 degli Studi di Padova, Policlinico di Borgo Roma, Verona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"Vettore","sequence":"additional","affiliation":[{"name":"Istituto di Patologia Speciale Medica e Sezione di Ematologia, Universit\u00e0 degli Studi di Padova, Policlinico di Borgo Roma, Verona"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1978,2,1]]},"reference":[{"key":"bibr1-030089167806400106","doi-asserted-by":"publisher","DOI":"10.1136\/adc.47.254.671-a"},{"key":"bibr2-030089167806400106","first-page":"225","volume":"3","author":"Aragon De La Cruz G.","year":"1975","journal-title":"Rev. Clin. Espa\u00f1."},{"key":"bibr3-030089167806400106","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.19.5.498"},{"key":"bibr4-030089167806400106","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1973.tb01678.x"},{"key":"bibr5-030089167806400106","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196804)21:4<743::AID-CNCR2820210427>3.0.CO;2-A"},{"key":"bibr6-030089167806400106","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197306)31:6<1337::AID-CNCR2820310606>3.0.CO;2-W"},{"key":"bibr7-030089167806400106","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197312)32:6<1512::AID-CNCR2820320631>3.0.CO;2-P"},{"key":"bibr8-030089167806400106","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)90353-9"},{"key":"bibr9-030089167806400106","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197008)26:2<332::AID-CNCR2820260214>3.0.CO;2-J"},{"key":"bibr10-030089167806400106","doi-asserted-by":"publisher","DOI":"10.1177\/030089167506100205"},{"key":"bibr11-030089167806400106","doi-asserted-by":"publisher","DOI":"10.1172\/JCI102743"},{"key":"bibr12-030089167806400106","doi-asserted-by":"publisher","DOI":"10.1159\/000206463"},{"key":"bibr13-030089167806400106","doi-asserted-by":"publisher","DOI":"10.1177\/030089167706300208"},{"key":"bibr14-030089167806400106","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)91199-3"},{"key":"bibr15-030089167806400106","first-page":"1723","volume":"31","author":"Teillet F.","year":"1971","journal-title":"Cancer Res."},{"key":"bibr16-030089167806400106","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197201)29:1<173::AID-CNCR2820290127>3.0.CO;2-1"},{"key":"bibr17-030089167806400106","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197302)31:2<303::AID-CNCR2820310206>3.0.CO;2-8"},{"key":"bibr18-030089167806400106","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197208)30:2<358::AID-CNCR2820300209>3.0.CO;2-H"},{"key":"bibr19-030089167806400106","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197607)38:1<225::AID-CNCR2820380134>3.0.CO;2-#"},{"key":"bibr20-030089167806400106","first-page":"1217","volume":"49","author":"Tura S.","year":"1968","journal-title":"G. Clin. Med."},{"key":"bibr21-030089167806400106","first-page":"1090","volume":"49","author":"Tura S.","year":"1968","journal-title":"G. Clin. Med."},{"key":"bibr22-030089167806400106","first-page":"699","author":"Weissman N.","year":"1974","journal-title":"Clinical Chemistry. Principles and Technics."}],"container-title":["Tumori Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089167806400106","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030089167806400106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:29:05Z","timestamp":1777660145000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030089167806400106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,2]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1978,2]]}},"alternative-id":["10.1177\/030089167806400106"],"URL":"https:\/\/doi.org\/10.1177\/030089167806400106","relation":{},"ISSN":["0300-8916","2038-2529"],"issn-type":[{"value":"0300-8916","type":"print"},{"value":"2038-2529","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,2]]}}}